The primary cilium is a hair-like surface-exposed organelle of the eukaryotic cell that
decodes a variety of signals—such as odorants, light and Hedgehog morphogens—by …

Inherited retinal degeneration (RD) leads to the impairment or loss of vision in millions of
individuals worldwide, most frequently due to the loss of photoreceptor (PR) cells. Animal …

Primary cilia project from the surface of most vertebrate cells and are key in sensing
extracellular signals and locally transducing this information into a cellular response. Recent …

An emerging number of rare genetic disorders termed ciliopathies are associated with
pediatric obesity. It is becoming clear that the mechanisms associated with cilia dysfunction …

Olfactory sensory neurons (OSNs) are bipolar neurons, unusual because they turn over
continuously and have a multiciliated dendrite. The extensive changes in gene expression …

A subset of genetic disorders termed ciliopathies are associated with obesity. The
mechanisms behind cilia dysfunction and altered energy homeostasis in these syndromes …

The primary cilium is an organelle that nearly all cells within the body contain. Its function is
to sense the extracellular environment through its abundance of receptors and linked …

Genome‐wide association studies have revealed a plethora of genetic variants that
correlate with polygenic conditions. However, causal molecular mechanisms have proven …

Primary cilia have well characterized roles in early brain development, relaying signals
critical for neurogenesis and brain formation during embryonic stages. Less understood are …

Background: Pediatric Intestinal Pseudo-obstruction (PIPO) is a congenital enteric disorder
characterized by severe gastrointestinal (GI) dysmotility, without mechanical obstruction …