The development of cancer is due to the accumulation of multiple somatic mutations and in
some cases due to germline mutations, which occur in malignancies such as retinoblastoma …

The history of tyrosine kinase oncogenes can be traced to 1911 when Peyton Rous, of the
Rockefeller Institute, demonstrated that a chicken tumor could be wx transplanted using a …

Cancer progression to the invasive and metastatic stage represents the most formidable
barrier to successful treatment. To develop rational therapies, we must determine the …

Background: Tobacco smoking has been observed to cause molecular alterations in
bronchial epithelium that antedate the development of lung carcinoma. The rising …

The roles of glycosaminoglycans and proteoglycans in the physiology of the urinary tract are
reviewed. The structures of proteoglycans and glycosaminoglycans are reviewed together …

Actin was first identified in non-muscle cells only about three decades ago, and at about the
same time, it was found that actin filaments were disrupted in the malignant transformed …

This study was conducted to investigate chemopreventive effects of Ganoderma lucidum
using a unique in vitro human urothelial cell (HUC) model consisted of HUC-PC cells and …

PURPOSE: To report a single biomarker, psoriasin (Mr 11.0 kd, pI 6.2), a calcium binding
protein which is expressed largely by stratified squamous epithelia and is externalized to the …

The study of physical and mechanical features of cancer cells, or cancer cell
mechanobiology, is a new frontier in cancer research. Such studies may enhance our …

Background The basis for bladder cancer development and progression is complex and
involves genetic abnormalities. These abnormalities yield phenotypic changes that allow …