Advances in targeted proteomics and applications to biomedical research
Targeted proteomics technique has emerged as a powerful protein quantification tool in
systems biology, biomedical research, and increasing for clinical applications. The most …
systems biology, biomedical research, and increasing for clinical applications. The most …
Parkinson disease
T Capriotti, K Terzakis - Home healthcare now, 2016 - journals.lww.com
Parkinson disease (PD) is a progressive neurodegenerative disease that affects one million
people in the United States. This article reviews the etiology and pathophysiology of PD, risk …
people in the United States. This article reviews the etiology and pathophysiology of PD, risk …
Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay
WE Heywood, D Galimberti, E Bliss, E Sirka… - Molecular …, 2015 - Springer
Background Currently there are no effective treatments for many neurodegenerative
diseases. Reliable biomarkers for identifying and stratifying these diseases will be important …
diseases. Reliable biomarkers for identifying and stratifying these diseases will be important …
N-GlycositeAtlas: a database resource for mass spectrometry-based human N-linked glycoprotein and glycosylation site mapping
Background N-linked glycoprotein is a highly interesting class of proteins for clinical and
biological research. The large-scale characterization of N-linked glycoproteins …
biological research. The large-scale characterization of N-linked glycoproteins …
Mass spectrometry: A platform for biomarker discovery and validation for Alzheimer's and Parkinson's diseases
EM Cilento, L Jin, T Stewart, M Shi… - Journal of …, 2019 - Wiley Online Library
Accurate, reliable, and objective biomarkers for Alzheimer's disease (AD), Parkinson's
disease (PD), and related age‐associated neurodegenerative disorders are urgently …
disease (PD), and related age‐associated neurodegenerative disorders are urgently …
Plasma MIA, CRP, and albumin predict cognitive decline in Parkinson's disease
Objective Using a multi‐cohort, discovery‐replication‐validation design, we sought new
plasma biomarkers that predict which individuals with Parkinson's disease (PD) will …
plasma biomarkers that predict which individuals with Parkinson's disease (PD) will …
Proteomics in human Parkinson's disease: present scenario and future directions
Parkinson's disease (PD) is an age-related, threatening neurodegenerative disorder with no
reliable treatment till date. Identification of specific and reliable biomarker is a major …
reliable treatment till date. Identification of specific and reliable biomarker is a major …
Site-Specific Profiling of Serum Glycoproteins Using N-Linked Glycan and Glycosite Analysis Revealing Atypical N-Glycosylation Sites on Albumin and α-1B …
Most serum proteins are N-linked glycosylated, and therefore the glycoproteomic profiling of
serum is essential for characterization of serum proteins. In this study, we profiled serum N …
serum is essential for characterization of serum proteins. In this study, we profiled serum N …
Plasma proteomics identify biomarkers predicting Parkinson's disease up to 7 years before symptom onset
J Hällqvist, M Bartl, M Dakna, S Schade… - Nature …, 2024 - nature.com
Parkinson's disease is increasingly prevalent. It progresses from the pre-motor stage
(characterised by non-motor symptoms like REM sleep behaviour disorder), to the disabling …
(characterised by non-motor symptoms like REM sleep behaviour disorder), to the disabling …
Mapping human N-linked glycoproteins and glycosylation sites using mass spectrometry
L Dang, L Jia, Y Zhi, P Li, T Zhao, B Zhu, R Lan… - TrAC Trends in …, 2019 - Elsevier
N-linked glycoprotein is a highly interesting class of proteins for clinical and biological
research. Over the last decade, large-scale profiling of N-linked glycoproteins and …
research. Over the last decade, large-scale profiling of N-linked glycoproteins and …