The GATA family of transcription factors consists of six proteins (GATA1-6) which are
involved in a variety of physiological and pathological processes. GATA1/2/3 are required …

Artificial intelligence (AI) is one of the key drivers of digital health. Digital health and AI
applications in medicine and biology are emerging worldwide, not only in resource-rich but …

Genome-wide association studies have identified 240 independent loci associated with type
2 diabetes (T2D) risk, but this knowledge has not advanced precision medicine. In contrast …

Bicuspid aortic valve (BAV) is a heritable congenital heart defect and an important risk factor
for valvulopathy and aortopathy. Here we report a genome-wide association scan of 466 …

Aims The present study aims to characterize the genetic risk architecture of bicuspid aortic
valve (BAV) disease, the most common congenital heart defect. Methods and results We …

Although the mammalian heart can regenerate during the neonatal stage, this endogenous
regenerative capacity is lost with age. Importantly, replication of cardiomyocytes has been …

Bicuspid aortic valve (BAV) is the most common form of congenital cardiovascular defect in
humans worldwide and is responsible for substantial morbidity and mortality. Accumulating …

The most frequent chromosomal structural loss in hepatocellular carcinoma (HCC) is of the
short arm of chromosome 8 (8p). Genes on the remaining homologous chromosome …

Congenital heart disease (CHD) is the most common birth defect in humans, and the
etiology of most CHD remains to be elusive. Atrial septal defect (ASD) makes up 30–40% of …

Study of monogenic congenital heart disease (CHD) has provided entry points to gain new
understanding of heart development and the molecular pathogenesis of CHD. In this review …