Mechanisms of tendon injury and repair
S Thomopoulos, WC Parks, DB Rifkin… - Journal of …, 2015 - Wiley Online Library
Tendon disorders are common and lead to significant disability, pain, healthcare cost, and
lost productivity. A wide range of injury mechanisms exist leading to tendinopathy or tendon …
lost productivity. A wide range of injury mechanisms exist leading to tendinopathy or tendon …
Tendon development and musculoskeletal assembly: emerging roles for the extracellular matrix
A Subramanian, TF Schilling - Development, 2015 - journals.biologists.com
Tendons and ligaments are extracellular matrix (ECM)-rich structures that interconnect
muscles and bones. Recent work has shown how tendon fibroblasts (tenocytes) interact with …
muscles and bones. Recent work has shown how tendon fibroblasts (tenocytes) interact with …
Mechanical regulation of musculoskeletal system development
N Felsenthal, E Zelzer - Development, 2017 - journals.biologists.com
During embryogenesis, the musculoskeletal system develops while containing within itself a
force generator in the form of the musculature. This generator becomes functional relatively …
force generator in the form of the musculature. This generator becomes functional relatively …
Directionality of developing skeletal muscles is set by mechanical forces
Formation of oriented myofibrils is a key event in musculoskeletal development. However,
the mechanisms that drive myocyte orientation and fusion to control muscle directionality in …
the mechanisms that drive myocyte orientation and fusion to control muscle directionality in …
Mechanical force regulates tendon extracellular matrix organization and tenocyte morphogenesis through TGFbeta signaling
Mechanical forces between cells and extracellular matrix (ECM) influence cell shape and
function. Tendons are ECM-rich tissues connecting muscles with bones that bear extreme …
function. Tendons are ECM-rich tissues connecting muscles with bones that bear extreme …
TGFβ and FGF promote tendon progenitor fate and act downstream of muscle contraction to regulate tendon differentiation during chick limb development
E Havis, MA Bonnin, J Esteves de Lima… - …, 2016 - journals.biologists.com
The molecular programme underlying tendon development has not been fully identified.
Interactions with components of the musculoskeletal system are important for limb tendon …
Interactions with components of the musculoskeletal system are important for limb tendon …
Tendon development and diseases
L Gaut, D Duprez - Wiley Interdisciplinary Reviews …, 2016 - Wiley Online Library
Tendon is a uniaxial connective tissue component of the musculoskeletal system. Tendon is
involved in force transmission between muscle and bone. Tendon injury is very common …
involved in force transmission between muscle and bone. Tendon injury is very common …
Thrombospondin-4 controls matrix assembly during development and repair of myotendinous junctions
A Subramanian, TF Schilling - Elife, 2014 - elifesciences.org
Tendons are extracellular matrix (ECM)-rich structures that mediate muscle attachments with
the skeleton, but surprisingly little is known about molecular mechanisms of attachment …
the skeleton, but surprisingly little is known about molecular mechanisms of attachment …
Molecular regulation of tendon cell fate during development
Although there have been several advances identifying novel mediators of tendon induction,
differentiation, and patterning, much of the basic landscape of tendon biology from …
differentiation, and patterning, much of the basic landscape of tendon biology from …
Development and maintenance of tendons and ligaments
Tendons and ligaments are fibrous connective tissues vital to the transmission of force and
stabilization of the musculoskeletal system. Arising in precise regions of the embryo …
stabilization of the musculoskeletal system. Arising in precise regions of the embryo …