Depression, one of the most common comorbidities with osteoarthritis (OA), affects patient
prognosis and quality of life. It also increases the overall burden of disease. This subgroup …

The sympathetic nervous system (SNS) is a major regulatory mediator connecting the brain
and the immune system that influences accordingly inflammatory processes within the entire …

Chronic osteoarthritis pain is accompanied by several comorbidities whose treatment has
not been completely resolved. The anti-inflammatory, analgesic, and antidepressant effects …

The pain-relieving properties of opioids in inflammatory and neuropathic pain are
heightened by hydrogen sulfide (H2S). However, whether allodynia and functional and/or …

Abstract Background and Objectives Chronic pain (CP) and cognitive decline (CD) are
highly comorbid and debilitating among older adults. We iteratively developed Active Brains …

Background Although depressive and anxious symptoms negatively impact musculoskeletal
health and orthopedic outcomes, a gap remains in identifying modalities through which …

Knee Osteoarthritis (KOA), the most prevalent joint disease, significantly impacts elderly
mobility due to progressive cartilage degeneration. Early prediction is crucial for preventing …

Background Knee osteoarthritis (KOA) is the most common joint disorder in the United
States and a leading cause of disability. Depression and obesity are highly comorbid with …

Objectives: Acute orthopedic traumatic musculoskeletal injuries are prevalent, costly, and
often lead to persistent pain and functional limitations. Psychological risk factors (pain …

Efforts to mitigate or prevent painful disabling osteoarthritis have been pursued for more
than a century. This current overview briefly summarizes the potential value of selected …