The liver is the only solid organ that uses regenerative mechanisms to ensure that the liver-
to-bodyweight ratio is always at 100% of what is required for body homeostasis. Other solid …

Liver regeneration is a complex process involving the crosstalk of multiple cell types,
including hepatocytes, hepatic stellate cells, endothelial cells and inflammatory cells. The …

Acetaminophen (APAP) overdose is the clinically most relevant drug hepatotoxicity in
western countries, and, because of translational relevance of animal models, APAP is …

Acetaminophen (APAP) is one of the most popular and safe pain medications worldwide.
However, due to its wide availability, it is frequently implicated in intentional or unintentional …

Liver regeneration has been studied for many decades and the mechanisms underlying
regeneration of the normal liver following resection or moderate damage are well described …

Signals related to liver regeneration (LR) have been identified by triggering proliferation in
hepatocyte cultures, delay of regeneration associated with signal ablation in genomically …

The conclusive identity of Wnts regulating liver zonation (LZ) and regeneration (LR) remains
unclear despite an undisputed role of β-catenin. Using single-cell analysis, we identified a …

Acetaminophen (N-acetyl-para-aminophenol; APAP) overdose is the most common cause of
acute liver failure in the Western world, with limited treatment opportunities. For years …

Acute liver failure can be the consequence of various etiologies, with most cases arising
from drug-induced hepatotoxicity in Western countries. Despite advances in this field, the …

Acetaminophen (APAP) is a widely used analgesic drug, which can cause severe liver injury
after an overdose. The intracellular signaling mechanisms of APAP-induced cell death such …