miRNA interplay: mechanisms and consequences in cancer
M Hill, N Tran - Disease models & mechanisms, 2021 - journals.biologists.com
Canonically, microRNAs (miRNAs) control mRNA expression. However, studies have shown
that miRNAs are also capable of targeting non-coding RNAs, including long non-coding …
that miRNAs are also capable of targeting non-coding RNAs, including long non-coding …
[HTML][HTML] Tumor suppressor miRNA in cancer cells and the tumor microenvironment: mechanism of deregulation and clinical implications
K Otmani, P Lewalle - Frontiers in oncology, 2021 - frontiersin.org
MicroRNAs (miRNAs) are noncoding RNAs that have been identified as important
posttranscriptional regulators of gene expression. miRNAs production is controlled at …
posttranscriptional regulators of gene expression. miRNAs production is controlled at …
DICER ribonuclease removes harmful R-loops
R-loops, which consist of a DNA-RNA hybrid and a displaced DNA strand, are known to
threaten genome integrity. To counteract this, different mechanisms suppress R-loop …
threaten genome integrity. To counteract this, different mechanisms suppress R-loop …
Ten years of DICER1 mutations: Provenance, distribution, and associated phenotypes
L de Kock, MK Wu, WD Foulkes - Human Mutation, 2019 - Wiley Online Library
DICER1 syndrome is a pleiotropic tumor predisposition syndrome characterized by a
distinctive constellation of neoplastic and dysplastic lesions, which are generally rare and …
distinctive constellation of neoplastic and dysplastic lesions, which are generally rare and …
miRNA biogenesis and inherited disorders: clinico-molecular insights
D Pelletier, B Rivera, MR Fabian, WD Foulkes - Trends in Genetics, 2023 - cell.com
MicroRNAs (miRNAs) play vital roles in the regulation of gene expression, a process known
as miRNA-induced gene silencing. The human genome codes for many miRNAs, and their …
as miRNA-induced gene silencing. The human genome codes for many miRNAs, and their …
[HTML][HTML] Secondary structure RNA elements control the cleavage activity of DICER
The accurate and efficient cleavage of shRNAs and pre-miRNAs by DICER is crucial for their
gene-silencing activity. Here, we conduct high-throughput DICER cleavage assays for more …
gene-silencing activity. Here, we conduct high-throughput DICER cleavage assays for more …
[HTML][HTML] ETMR: a tumor entity in its infancy
Abstract Embryonal tumor with Multilayered Rosettes (ETMR) is a relatively rare but typically
deadly type of brain tumor that occurs mostly in infants. Since the discovery of the …
deadly type of brain tumor that occurs mostly in infants. Since the discovery of the …
[HTML][HTML] DICER1 syndrome and cancer predisposition: from a rare pediatric tumor to lifetime risk
AM Caroleo, MA De Ioris, L Boccuto, I Alessi… - Frontiers in …, 2021 - frontiersin.org
DICER1 syndrome is a rare genetic condition predisposing to hereditary cancer and caused
by variants in the DICER1 gene. The risk to present a neoplasm before the age of 10 years …
by variants in the DICER1 gene. The risk to present a neoplasm before the age of 10 years …
[HTML][HTML] Genetic and epigenetic causes of pituitary adenomas
M Chang, C Yang, X Bao, R Wang - Frontiers in endocrinology, 2021 - frontiersin.org
Pituitary adenomas (PAs) can be classified as non-secreting adenomas, somatotroph
adenomas, corticotroph adenomas, lactotroph adenomas, and thyrotroph adenomas …
adenomas, corticotroph adenomas, lactotroph adenomas, and thyrotroph adenomas …
Discrimination between cancer cells and DNA-damaged cells: pre-miRNA region recognition based on hyperbranched hybrid chain reaction amplification for …
J Zhou, X Peng, Z Yang, Y Zhuo, W Liang… - Analytical …, 2022 - ACS Publications
Herein, a novel region recognition of precursor microRNA (Pre-miRNA) based on
hyperbranched hybrid chain reaction (HB-HCR) amplification was constructed to effectively …
hyperbranched hybrid chain reaction (HB-HCR) amplification was constructed to effectively …