Delivery of effective anti-leukemic agents to the central nervous system (CNS) is considered
essential for cure of childhood acute lymphoblastic leukemia. Current CNS-directed therapy …

Simple Summary The central nervous system constitutes a unique microenvironment to
which access is highly restricted. However, immune cells enter as part of their normal routine …

The identification of genetic factors that regulate the cancer immune microenvironment is
important for understanding the mechanism of tumor progression and establishing an …

Runt-related transcription factor 1 (RUNX1) is oncogenic in diverse types of leukemia and
epithelial cancers where its expression is associated with poor prognosis. Current models …

Objective To analyze the abundance of infiltrating tumor immune cells in patients with oral
squamous cell carcinoma (OSCC) and to search for potential targets that can predict patient …

Infant and adult MLL1/KMT2A-rearranged (MLLr) leukemia represents a disease with a
dismal prognosis. Here, we present a functional and proteomic characterization of in utero …

Minimal residual disease (MRD) detection is an important prognostic parameter in patients
with refractory or relapsed B-cell acute lymphoblastic leukemia (R/R B-ALL). CD79a has …

This study sought to identify molecular subtypes of breast cancer (BC) and develop a breast
cancer stem cells (BCSCs)-related gene risk score for predicting prognosis and assessing …

Acute lymphoblastic leukemia (ALL) arises from the uncontrolled proliferation of B-cell
precursors (BCP-ALL) or T cells (T-ALL). Current treatment protocols obtain high cure rates …

Background Rare oncogenic driver events, particularly affecting the expression or splicing of
driver genes, are suspected to substantially contribute to the large heterogeneity of …