During microbial infection, pre-existing memory CD8+ T cells that are not specific for the
infecting pathogens can be activated by cytokines without cognate antigens, termed …

There is an urgent need for new strategies to combat infectious diseases in developing
countries. Many pathogens have evolved to elude immunity and this has limited the utility of …

Acute hepatitis A (AHA) involves severe CD8+ T cell-mediated liver injury. Here we showed
during AHA, CD8+ T cells specific to unrelated viruses became activated. Hepatitis A virus …

Immune cell-specific expression is one indication of the importance of a gene's role in the
immune response. We have compiled a compendium of microarray expression data for …

T cell large granular lymphocyte (T-LGL) leukemia features a clonal expansion of antigen-
primed, competent, cytotoxic T lymphocytes (CTL). To systematically understand signaling …

Graft-versus-host disease (GVHD) is caused by alloreactive donor T cells that trigger host
tissue injury. GVHD develops over weeks or months, but how this immune response is …

Mitophagy, a central process guarding mitochondrial quality, is commonly impaired in
human diseases such as Parkinson's disease, but its impact in adaptive immunity remains …

Myeloid-derived suppressor cells (MDSCs) have the capacity to suppress T-cell–mediated
immune responses and impact the clinical outcome of cancer, infections, and transplantation …

BACKGROUND: Aspiration of gastroesophageal refluxate may contribute to lung transplant
bronchiolitis obliterans syndrome (BOS). We investigated bile acids in bronchoalveolar …

BACKGROUND The biology of Plasmodium vivax is markedly different from that of P.
falciparum; how this shapes the immune response to infection remains unclear. To address …