[HTML][HTML] Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?
SE Engelen, AJB Robinson, YX Zurke… - Nature Reviews …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …
formation of plaques containing lipid, connective tissue and immune cells in the intima of …
Interleukin-6 signaling and anti-interleukin-6 therapeutics in cardiovascular disease
PM Ridker, M Rane - Circulation research, 2021 - Am Heart Assoc
IL (interleukin)-6 is a pivotal cytokine of innate immunity, which enacts a broad set of
physiological functions traditionally associated with host defense, immune cell regulation …
physiological functions traditionally associated with host defense, immune cell regulation …
Inflammation and cholesterol as predictors of cardiovascular events among patients receiving statin therapy: a collaborative analysis of three randomised trials
Background Inflammation and hyperlipidaemia jointly contribute to atherothrombotic
disease. However, when people are treated with intensive statin therapy, the relative …
disease. However, when people are treated with intensive statin therapy, the relative …
Myocardial ischemia-reperfusion injury and the influence of inflammation
Acute myocardial infarction is caused by a sudden coronary artery occlusion and leads to
ischemia in the corresponding myocardial territory which generally results in myocardial …
ischemia in the corresponding myocardial territory which generally results in myocardial …
Targeting the NLRP3 inflammasome in cardiovascular diseases
The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …
Targeting innate immunity-driven inflammation in CKD and cardiovascular disease
T Speer, S Dimmeler, SJ Schunk, D Fliser… - Nature Reviews …, 2022 - nature.com
Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …
Macrophages in cardiac remodelling after myocardial infarction
J Yap, J Irei, J Lozano-Gerona, S Vanapruks… - Nature Reviews …, 2023 - nature.com
Myocardial infarction (MI), as a result of thrombosis or vascular occlusion, is the most
prevalent cause of morbidity and mortality among all cardiovascular diseases. The …
prevalent cause of morbidity and mortality among all cardiovascular diseases. The …
The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases
An intense, stereotyped inflammatory response occurs in response to ischaemic and non-
ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein …
ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein …
[HTML][HTML] A fresh look at coronary microembolization
P Kleinbongard, G Heusch - Nature Reviews Cardiology, 2022 - nature.com
Mechanical stress from haemodynamic perturbations or interventional manipulation of
epicardial coronary atherosclerotic plaques with inflammatory destabilization can release …
epicardial coronary atherosclerotic plaques with inflammatory destabilization can release …
Effect of colchicine on myocardial injury in acute myocardial infarction
N Mewton, F Roubille, D Bresson, C Prieur, C Bouleti… - Circulation, 2021 - Am Heart Assoc
Background: Inflammation is a key factor of myocardial damage in reperfused ST-segment–
elevation myocardial infarction. We hypothesized that colchicine, a potent anti-inflammatory …
elevation myocardial infarction. We hypothesized that colchicine, a potent anti-inflammatory …