Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal
tract. Cytokine-targeted therapies have transformed the treatment of IBD, providing control of …

Background The intestinal mucosa is composed of a well-organized epithelium, acting as a
physical barrier to harmful luminal contents, while simultaneously ensuring absorption of …

The mucosal origins hypothesis of rheumatoid arthritis (RA) proposes a central role for
mucosal immune responses in the initiation or perpetuation of the systemic autoimmunity …

The intestine serves as both our largest single barrier to the external environment and the
host of more immune cells than any other location in our bodies. Separating these potential …

The intestinal barrier encompasses structural, permeability and immune aspects of the gut
mucosa that, when disrupted, may contribute to chronic inflammation. Although gnotobiotic …

The mammalian intestine harbors a remarkable number of microbes and their components
and metabolites, which are fundamental for the instigation and development of the host …

The prevalence of non-alcoholic fatty liver disease (NAFLD) has soared globally. As our
understanding of the disease grows, the role of the gut-liver axis (GLA) in NAFLD …

Gluten-related disorders include distinct disease entities, namely celiac disease, wheat-
associated allergy and non-celiac gluten/wheat sensitivity. Despite having in common the …

Altered intestinal microbiota is associated with systemic and intestinal diseases, such as
inflammatory bowel disease (IBD). Dysbiotic microbiota with enhanced proinflammatory …

Intact epithelial barrier and mucosal immune system are crucial for maintaining intestinal
homeostasis. Previous study indicated that Dendrobium officinale polysaccharides (DOPS) …