Modeling the neuroimmune system in Alzheimer's and Parkinson's diseases
W Balestri, R Sharma, VA da Silva, BC Bobotis… - Journal of …, 2024 - Springer
Parkinson's disease (PD) and Alzheimer's disease (AD) are neurodegenerative disorders
caused by the interaction of genetic, environmental, and familial factors. These diseases …
caused by the interaction of genetic, environmental, and familial factors. These diseases …
Leveraging iPSC technology to assess neuro-immune interactions in neurological and psychiatric disorders
C Michalski, Z Wen - Frontiers in Psychiatry, 2023 - frontiersin.org
Communication between the immune and the nervous system is essential for human brain
development and homeostasis. Disruption of this intricately regulated crosstalk can lead to …
development and homeostasis. Disruption of this intricately regulated crosstalk can lead to …
Botulinum Neurotoxin Induces Neurotoxic Microglia Mediated by Exogenous Inflammatory Responses
Botulinum neurotoxin serotype A (BoNT/A) is widely used in therapeutics and cosmetics.
The effects of multi‐dosed BoNT/A treatment are well documented on the peripheral nervous …
The effects of multi‐dosed BoNT/A treatment are well documented on the peripheral nervous …
Advancing nerve regeneration: Peripheral nerve injury (PNI) chip empowering high-speed biomaterial and drug screening
Peripheral nerve injuries (PNIs) represent a significant challenge in regenerative medicine,
often leading to long-term functional impairments. In this study, we introduce the peripheral …
often leading to long-term functional impairments. In this study, we introduce the peripheral …
Environmental aluminum oxide inducing neurodegeneration in human neurovascular unit with immunity
Aluminum oxide nanoparticle (AlNP), a ubiquitous neurotoxin highly enriched in air
pollution, is often produced as an inevitable byproduct in the manufacturing of industrial …
pollution, is often produced as an inevitable byproduct in the manufacturing of industrial …
[HTML][HTML] Electrophysiological features of cortical 3D networks are deeply modulated by scaffold properties
Three-dimensionality (3D) was proven essential for developing reliable models for different
anatomical compartments and many diseases. However, the neuronal compartment still …
anatomical compartments and many diseases. However, the neuronal compartment still …
Human In Vitro Models of Neuroenergetics and Neurometabolic Disturbances: Current Advances and Clinical Perspectives
J Rogal, LN Zamproni, P Nikolakopoulou… - Stem Cells …, 2024 - academic.oup.com
Neurological conditions conquer the world; they are the leading cause of disability and the
second leading cause of death worldwide, and they appear all around the world in every …
second leading cause of death worldwide, and they appear all around the world in every …
Microbiome-derived indole-3-lactic acid reduces amyloidopathy through aryl-hydrocarbon receptor activation
Alzheimer's disease (AD) pathogenesis has been associated with the gut microbiome and
its metabolites, though the specific mechanisms have remained unclear. In our study, we …
its metabolites, though the specific mechanisms have remained unclear. In our study, we …
Neuroinflammation-on-a-chip for multiple sclerosis research: a narrative review
C Berjaoui, C Kachouh, S Joumaa… - Annals of Medicine …, 2024 - journals.lww.com
Aim: The main aim of this research paper “Neuroinflammation-on-a-Chip” for studying
multiple sclerosis is to enhance our comprehension of MS development, demonstrate the …
multiple sclerosis is to enhance our comprehension of MS development, demonstrate the …
Human Brain In Vitro Model for Pathogen Infection-Related Neurodegeneration Study
Y Yan, AN Cho - International Journal of Molecular Sciences, 2024 - mdpi.com
Recent advancements in stem cell biology and tissue engineering have revolutionized the
field of neurodegeneration research by enabling the development of sophisticated in vitro …
field of neurodegeneration research by enabling the development of sophisticated in vitro …