Modeling the neuroimmune system in Alzheimer's and Parkinson's diseases

W Balestri, R Sharma, VA da Silva, BC Bobotis… - Journal of …, 2024 - Springer
Parkinson's disease (PD) and Alzheimer's disease (AD) are neurodegenerative disorders
caused by the interaction of genetic, environmental, and familial factors. These diseases …

Leveraging iPSC technology to assess neuro-immune interactions in neurological and psychiatric disorders

C Michalski, Z Wen - Frontiers in Psychiatry, 2023 - frontiersin.org
Communication between the immune and the nervous system is essential for human brain
development and homeostasis. Disruption of this intricately regulated crosstalk can lead to …

Botulinum Neurotoxin Induces Neurotoxic Microglia Mediated by Exogenous Inflammatory Responses

G Ambrin, YJ Kang, K Van Do, C Lee… - Advanced …, 2024 - Wiley Online Library
Botulinum neurotoxin serotype A (BoNT/A) is widely used in therapeutics and cosmetics.
The effects of multi‐dosed BoNT/A treatment are well documented on the peripheral nervous …

Advancing nerve regeneration: Peripheral nerve injury (PNI) chip empowering high-speed biomaterial and drug screening

D Lee, HQ Tran, AT Dudley, K Yang, Z Yan… - Chemical Engineering …, 2024 - Elsevier
Peripheral nerve injuries (PNIs) represent a significant challenge in regenerative medicine,
often leading to long-term functional impairments. In this study, we introduce the peripheral …

Environmental aluminum oxide inducing neurodegeneration in human neurovascular unit with immunity

Y Xue, M Tran, YN Diep, S Shin, J Lee, H Cho… - Scientific Reports, 2024 - nature.com
Aluminum oxide nanoparticle (AlNP), a ubiquitous neurotoxin highly enriched in air
pollution, is often produced as an inevitable byproduct in the manufacturing of industrial …

[HTML][HTML] Electrophysiological features of cortical 3D networks are deeply modulated by scaffold properties

F Callegari, M Brofiga, M Tedesco, P Massobrio - APL bioengineering, 2024 - pubs.aip.org
Three-dimensionality (3D) was proven essential for developing reliable models for different
anatomical compartments and many diseases. However, the neuronal compartment still …

Human In Vitro Models of Neuroenergetics and Neurometabolic Disturbances: Current Advances and Clinical Perspectives

J Rogal, LN Zamproni, P Nikolakopoulou… - Stem Cells …, 2024 - academic.oup.com
Neurological conditions conquer the world; they are the leading cause of disability and the
second leading cause of death worldwide, and they appear all around the world in every …

Microbiome-derived indole-3-lactic acid reduces amyloidopathy through aryl-hydrocarbon receptor activation

H Kim, E Lee, M Park, K Min, YN Diep, J Kim… - Brain, Behavior, and …, 2024 - Elsevier
Alzheimer's disease (AD) pathogenesis has been associated with the gut microbiome and
its metabolites, though the specific mechanisms have remained unclear. In our study, we …

Neuroinflammation-on-a-chip for multiple sclerosis research: a narrative review

C Berjaoui, C Kachouh, S Joumaa… - Annals of Medicine …, 2024 - journals.lww.com
Aim: The main aim of this research paper “Neuroinflammation-on-a-Chip” for studying
multiple sclerosis is to enhance our comprehension of MS development, demonstrate the …

Human Brain In Vitro Model for Pathogen Infection-Related Neurodegeneration Study

Y Yan, AN Cho - International Journal of Molecular Sciences, 2024 - mdpi.com
Recent advancements in stem cell biology and tissue engineering have revolutionized the
field of neurodegeneration research by enabling the development of sophisticated in vitro …