Recent advances in integrated microfluidics for liquid biopsies and future directions

J Zhuang, L Xia, Z Zou, J Yin, N Lin, Y Mu - Biosensors and Bioelectronics, 2022 - Elsevier
Liquid biopsies have piqued the interest of researchers as a new tumor diagnosis technique
due to their unique benefits of non-invasiveness, sensitivity, and convenience. Recent …

Passive microfluidic devices for cell separation

T Zhang, D Di Carlo, CT Lim, T Zhou, G Tian… - Biotechnology …, 2024 - Elsevier
The separation of specific cell populations is instrumental in gaining insights into cellular
processes, elucidating disease mechanisms, and advancing applications in tissue …

Cell separations and sorting

MA Witek, IM Freed, SA Soper - Analytical chemistry, 2019 - ACS Publications
The development of new methods and technologies for cell separation, sorting, selection,
isolation, or enrichment (many times the aforementioned terms are used interchangeably) …

Optomicrofluidic detection of cancer cells in peripheral blood via metabolic glycoengineering

K Mirkale, SK Jain, TS Oviya, S Mahalingam - Lab on a Chip, 2023 - pubs.rsc.org
The currently existing label-based techniques for the detection of circulating tumor cells
(CTCs) target natural surface proteins of cells and are therefore applicable to only limited …

Advances in single-cell metabolomics to unravel cellular heterogeneity in plant biology

K Pandian, M Matsui, T Hankemeier, A Ali… - Plant …, 2023 - academic.oup.com
Single-cell metabolomics is a powerful tool that can reveal cellular heterogeneity and can
elucidate the mechanisms of biological phenomena in detail. It is a promising approach in …

Migration and Spreading of Droplets across a Fluid–Fluid Interface in Microfluidic Coflow

S Hazra, S Mitra, AK Sen - Langmuir, 2022 - ACS Publications
Interfacial migration of droplets in microfluidic confinements has significant relevance in cell
biology and biochemical assays. So far, studies on passive interfacial migration of droplets …

Particle encapsulation in aqueous ferrofluid drops and sorting of particle-encapsulating drops from empty drops using a magnetic field

U Banerjee, SK Jain, AK Sen - Soft Matter, 2021 - pubs.rsc.org
Handling and manipulation of particle-encapsulating droplets (PED) have profound
applications in biochemical assays. Herein we report encapsulation of microparticles in …

Multiple-streams focusing-based cell separation in high viscoelasticity flow

H Feng, D Patel, JJ Magda, S Geher, PA Sigala… - ACS …, 2022 - ACS Publications
Viscoelastic flow has been widely used in microfluidic particle separation processes, in
which particles get focused on the channel center in diluted viscoelastic flow. In this paper …

An optomicrofluidic device for the detection and isolation of drop-encapsulated target cells in single-cell format

R Gaikwad, AK Sen - Analyst, 2021 - pubs.rsc.org
Single-cell analysis has emerged as a powerful method for genomics, transcriptomics,
proteomics, and metabolomics characterisation at the individual cell level. Here, we …

Trapping and coalescence of diamagnetic aqueous droplets using negative magnetophoresis

SK Jain, U Banerjee, AK Sen - Langmuir, 2020 - ACS Publications
The manipulation of aqueous droplets has a profound significance in biochemical assays.
Magnetic field-driven droplet manipulation, offering unique advantages, is consequently …