Pathogenic mechanisms underlying idiopathic pulmonary fibrosis

BJ Moss, SW Ryter, IO Rosas - Annual Review of Pathology …, 2022 - annualreviews.org
The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of cell
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …

Global incidence and prevalence of idiopathic pulmonary fibrosis

TM Maher, E Bendstrup, L Dron, J Langley, G Smith… - Respiratory …, 2021 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a progressive debilitating lung disease
with considerable morbidity. Heterogeneity in epidemiologic studies means the full impact of …

A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models

F Ren, A Aliper, J Chen, H Zhao, S Rao, C Kuppe… - Nature …, 2024 - nature.com
Idiopathic pulmonary fibrosis (IPF) is an aggressive interstitial lung disease with a high
mortality rate. Putative drug targets in IPF have failed to translate into effective therapies at …

Idiopathic pulmonary fibrosis: state of the art for 2023

AJ Podolanczuk, CC Thomson… - European …, 2023 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease characterised by
worsening respiratory symptoms and physiological impairment. Increasing awareness of the …

Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis

THG Phan, P Paliogiannis, GK Nasrallah… - Cellular and Molecular …, 2021 - Springer
Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …

Diagnosis of idiopathic pulmonary fibrosis. An official ATS/ERS/JRS/ALAT clinical practice guideline

G Raghu, M Remy-Jardin, JL Myers… - American journal of …, 2018 - atsjournals.org
Background: This document provides clinical recommendations for the diagnosis of
idiopathic pulmonary fibrosis (IPF). It represents a collaborative effort between the American …

Association between preserved ratio impaired spirometry and clinical outcomes in US adults

ES Wan, P Balte, JE Schwartz, SP Bhatt, PA Cassano… - Jama, 2021 - jamanetwork.com
Importance Chronic lung diseases are a leading cause of morbidity and mortality. Unlike
chronic obstructive pulmonary disease, clinical outcomes associated with proportional …

[HTML][HTML] The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity

CC Bain, AS MacDonald - Mucosal immunology, 2022 - Elsevier
The last decade has been somewhat of a renaissance period for the field of macrophage
biology. This renewed interest, combined with the advent of new technologies and …

Idiopathic pulmonary fibrosis

L Richeldi, HR Collard, MG Jones - The Lancet, 2017 - thelancet.com
Idiopathic pulmonary fibrosis is a prototype of chronic, progressive, and fibrotic lung disease.
Healthy tissue is replaced by altered extracellular matrix and alveolar architecture is …

Developmental pathways in the pathogenesis of lung fibrosis

D Chanda, E Otoupalova, SR Smith, T Volckaert… - Molecular aspects of …, 2019 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive and terminal lung disease with no known
cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival …