Commonalities in epileptogenic processes from different acute brain insults: Do they translate?
The most common forms of acquired epilepsies arise following acute brain insults such as
traumatic brain injury, stroke, or central nervous system infections. Treatment is effective for …
traumatic brain injury, stroke, or central nervous system infections. Treatment is effective for …
Post-traumatic epilepsy and comorbidities: advanced models, molecular mechanisms, biomarkers, and novel therapeutic interventions
Post-traumatic epilepsy (PTE) is one of the most devastating long-term, network
consequences of traumatic brain injury (TBI). There is currently no approved treatment that …
consequences of traumatic brain injury (TBI). There is currently no approved treatment that …
Single cell molecular alterations reveal target cells and pathways of concussive brain injury
The complex neuropathology of traumatic brain injury (TBI) is difficult to dissect, given the
convoluted cytoarchitecture of affected brain regions such as the hippocampus …
convoluted cytoarchitecture of affected brain regions such as the hippocampus …
Hippocampal neurophysiologic changes after mild traumatic brain injury and potential neuromodulation treatment approaches
Traumatic brain injury (TBI) is the leading cause of death and disability in individuals below
age 45, and five million Americans live with chronic disability as a result. Mild TBI (mTBI) …
age 45, and five million Americans live with chronic disability as a result. Mild TBI (mTBI) …
Novel therapeutic approaches for disease-modification of epileptogenesis for curing epilepsy
BL Clossen, DS Reddy - Biochimica et Biophysica Acta (BBA)-Molecular …, 2017 - Elsevier
This article describes the recent advances in epileptogenesis and novel therapeutic
approaches for the prevention of epilepsy, with a special emphasis on the pharmacological …
approaches for the prevention of epilepsy, with a special emphasis on the pharmacological …
Mammalian target of rapamycin (mTOR) signaling pathway and traumatic brain injury: A novel insight into targeted therapy
Traumatic brain injury (TBI) is one of the most concerning health issues in which the normal
brain function may be disrupted as a result of a blow, bump, or jolt to the head. Loss of …
brain function may be disrupted as a result of a blow, bump, or jolt to the head. Loss of …
Rapamycin improves the neuroprotection effect of inhibition of NLRP3 inflammasome activation after TBI
Y Chen, J Meng, Q Xu, T Long, F Bi, C Chang, W Liu - Brain research, 2019 - Elsevier
Inflammation is the focus of many studies on traumatic brain injury (TBI) treatment and
outcomes improvement. Some studies have demonstrated that the inhibition of NOD-like …
outcomes improvement. Some studies have demonstrated that the inhibition of NOD-like …
Impact of traumatic brain injury on neurogenesis
LB Ngwenya, SC Danzer - Frontiers in neuroscience, 2019 - frontiersin.org
New neurons are generated in the hippocampal dentate gyrus from early development
through adulthood. Progenitor cells and immature granule cells in the subgranular zone are …
through adulthood. Progenitor cells and immature granule cells in the subgranular zone are …
In search of antiepileptogenic treatments for post-traumatic epilepsy
Post-traumatic epilepsy (PTE) is diagnosed in 20% of individuals with acquired epilepsy,
and can impact significantly the quality of life due to the seizures and other functional or …
and can impact significantly the quality of life due to the seizures and other functional or …
Contusion brain damage in mice for modelling of post-traumatic epilepsy with contralateral hippocampus sclerosis: Comprehensive and longitudinal characterization …
Traumatic brain injury (TBI) is a leading cause of acquired epilepsy referred to as post-
traumatic epilepsy (PTE), characterized by spontaneous recurrent seizures (SRS) that start …
traumatic epilepsy (PTE), characterized by spontaneous recurrent seizures (SRS) that start …