Reactive oxygen species (ROS) are well known for their role in mediating both physiological
and pathophysiological signal transduction. Enzymes and subcellular compartments that …

Autophagy is a catabolic process for unnecessary or dysfunctional cytoplasmic contents by
lysosomal degradation pathways. Autophagy is implicated in various biological processes …

Mountainous evidence suggests that inflammation, cardiomyocyte apoptosis and pyroptosis
are involved in the development of sepsis and sepsis-induced cardiomyopathy (SIC) …

Background: Cardiac dysfunction is a major component of sepsis-induced multiorgan failure
in critical care units. Changes in cardiac autophagy and its role during sepsis pathogenesis …

Cardiovascular disease is the leading cause of morbidity and mortality worldwide.
Advancing age is a major risk factor for developing cardiovascular disease because of the …

Background Septic cardiomyopathy worsens the prognosis of critically ill patients. Clinical
data suggest that interleukin‐1β (IL‐1β), activated by the NLRP3 inflammasome …

Cardiovascular disease is a major leading cause of morbidity and mortality in the United
States and elsewhere. Alterations in mitochondrial function are increasingly being …

Background There is evidence for inflammation, autophagy, and apoptosis in the ischemic
heart. Autophagy is a physiologic process for tissue survival. Apoptosis, on the other hand, is …

Autophagy is a homeostatic process involved in the bulk degradation of cytoplasmic
components, including damaged organelles and proteins. In both genetic and dietary …

Macroautophagy/autophagy is a lysosome-dependent catabolic process for the turnover of
proteins and organelles in eukaryotes. Autophagy plays an important role in immunity and …