Antiviral drug delivery system for enhanced bioactivity, better metabolism and pharmacokinetic characteristics
R Chen, T Wang, J Song, D Pu, D He, J Li… - International journal …, 2021 - Taylor & Francis
Antiviral drugs (AvDs) are the primary resource in the global battle against viruses, including
the recent fight against corona virus disease 2019 (COVID-19). Most AvDs require multiple …
the recent fight against corona virus disease 2019 (COVID-19). Most AvDs require multiple …
Versatility of hydrogel-forming microneedles in in vitro transdermal delivery of tuberculosis drugs
QK Anjani, AD Permana, Á Cárcamo-Martínez… - European Journal of …, 2021 - Elsevier
Current therapy of tuberculosis (TB) has several limitations, such as risk of liver injury and
intestinal dysbiosis due to frequent oral administration of antibiotics. Transdermal …
intestinal dysbiosis due to frequent oral administration of antibiotics. Transdermal …
Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential
DR Telange, AT Patil, AM Pethe, H Fegade… - European Journal of …, 2017 - Elsevier
The apigenin-phospholipid phytosome (APLC) was developed to improve the aqueous
solubility, dissolution, in vivo bioavailability, and antioxidant activity of apigenin. The APLC …
solubility, dissolution, in vivo bioavailability, and antioxidant activity of apigenin. The APLC …
Recent advances in nanoformulation development of Ritonavir, a key protease inhibitor used in the treatment of HIV-AIDS
SR Jitta, Salwa, NA Bhaskaran… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction AIDS is one of the world's most serious public health challenges. Protease
inhibitors are key components of AIDS treatment regimen. Ritonavir is a well-known …
inhibitors are key components of AIDS treatment regimen. Ritonavir is a well-known …
Preparation and formula optimization of cephalexin loaded transferosomal gel by QbD to enhance the transdermal delivery: in vitro, ex vivo and in vivo study
Most antibiotics used in topical formulations are not absorbed by deeper skin layers and
subdermal tissues. Hence the skin infections are treated with large doses of oral or …
subdermal tissues. Hence the skin infections are treated with large doses of oral or …
Phospholipid complex-loaded self-assembled phytosomal soft nanoparticles: evidence of enhanced solubility, dissolution rate, ex vivo permeability, oral bioavailability …
DR Telange, NK Sohail, AT Hemke, PS Kharkar… - Drug Delivery and …, 2021 - Springer
In this study, self-assembled phytosomal soft nanoparticles encapsulated with phospholipid
complex (MPLC SNPs) using a combination of solvent evaporation and nanoprecipitation …
complex (MPLC SNPs) using a combination of solvent evaporation and nanoprecipitation …
Formulation of chitosan-coated apigenin bilosomes: in vitro characterization, antimicrobial and cytotoxicity assessment
SS Imam, S Alshehri, MA Altamimi, RKH Almalki… - Polymers, 2022 - mdpi.com
We prepared apigenin (APG)-loaded bilosomes (BLs) and evaluated them for vesicle size,
zeta-potential and encapsulation efficiency. The formulations were prepared with cholesterol …
zeta-potential and encapsulation efficiency. The formulations were prepared with cholesterol …
Effect of plasticizers on manufacturing ritonavir/copovidone solid dispersions via hot-melt extrusion: Preformulation, physicochemical characterization, and …
Y Zhao, X Xie, Y Zhao, Y Gao, C Cai, Q Zhang… - European Journal of …, 2019 - Elsevier
In this study, novel ritonavir solid dispersion (RTV SD) formulations were prepared with
copovidone (PVPVA 64) and optimized plasticizers via hot-melt extrusion (HME) at different …
copovidone (PVPVA 64) and optimized plasticizers via hot-melt extrusion (HME) at different …
Development and Characterization of Pentaerythritol-EudragitRS100 Co-processed Excipients as Solid Dispersion Carriers for Enhanced Aqueous Solubility, In Vitro …
DR Telange, NM Bhaktani, AT Hemke, AM Pethe… - ACS …, 2023 - ACS Publications
Atorvastatin (ATV), a lipid-lowering agent, has low oral bioavailability due to its poor water
solubility, permeability, and low dissolution rate. Therefore, pentaerythritol-EudragitRS100 …
solubility, permeability, and low dissolution rate. Therefore, pentaerythritol-EudragitRS100 …
Phospholipid based colloidal nanocarriers for enhanced solubility and therapeutic efficacy of withanolides
SD Saoji, NR Rarokar, PW Dhore, SO Dube… - Journal of Drug Delivery …, 2022 - Elsevier
The bioactive withanolides of Withania somnifera (WS) are reported to treat acute stress-
induced anxiety and chronic stress-induced depression. However, its biopharmaceutical …
induced anxiety and chronic stress-induced depression. However, its biopharmaceutical …