The implantation of any foreign material into the body leads to the development of an
inflammatory and fibrotic process—the foreign body reaction (FBR). Upon implantation into a …

Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …

Galectin (Gal)-3 is a profibrotic β-galactoside-binding lectin that plays a key role in the
pathogenesis of idiopathic pulmonary fibrosis (IPF) and IPF exacerbations. TD139 is a novel …

INTRODUCTION Fibroblasts produce extracellular matrix (ECM) molecules that regulate
tissue strength and resilience. Imbalanced ECM maintenance leads to tissue dysfunction …

Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease
characterised by fibrosis of the lung parenchyma and loss of lung function. Although the …

Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pulmonary
disease with a median survival of 2–4 years after diagnosis. A significant number of IPF …

Of the deaths attributed to cancer, 90% are due to metastasis, and treatments that prevent or
cure metastasis remain elusive. Emerging data indicate that hypoxia and the extracellular …

Fibrosis is a highly conserved and co-ordinated protective response to tissue injury. The
interaction of multiple pathways, molecules and systems determines whether fibrosis is self …

Mesenchymal stem cell (MSC)-derived exosomes mediate tissue regeneration in a variety of
diseases including ischemic heart injury, liver fibrosis, and cerebrovascular disease. Despite …

Body implants and implantable medical devices have dramatically improved and prolonged
the life of countless patients. However, our body repair mechanisms have evolved to isolate …