The Biosynthesis and Applications of Protein Lipidation

W Ding, J Gu, W Xu, J Wu, Y Huang, S Zhang… - Chemical …, 2024 - ACS Publications
Protein lipidation dramatically affects protein structure, localization, and trafficking via
remodeling protein–membrane and protein–protein interactions through hydrophobic lipid …

Introduction of Carbonyl Groups into Antibodies

EL Gulyak, VA Alferova, VA Korshun, KA Sapozhnikova - Molecules, 2023 - mdpi.com
Antibodies and their derivatives (scFv, Fabs, etc.) represent a unique class of biomolecules
that combine selectivity with the ability to target drug delivery. Currently, one of the most …

Broadening the Utility of Farnesyltransferase-Catalyzed Protein Labeling Using Norbornene–Tetrazine Click Chemistry

SA Auger, S Venkatachalapathy, KFG Suazo… - Bioconjugate …, 2024 - ACS Publications
Bioorthogonal chemistry has gained widespread use in the study of many biological systems
of interest, including protein prenylation. Prenylation is a post-translational modification, in …

Evaluating and Exploiting the Substrate Selectivity of Farnesyltransferase

GL Schey - 2023 - search.proquest.com
Protein prenylation is a post translational modification where an isoprenoid is attached to a
CaaX sequence at the c terminus of a protein. Ultimately, after this modification and …