Oxidative stress is a component of many diseases, including atherosclerosis, chronic
obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small …

Peroxynitrite—the product of the diffusion-controlled reaction of nitric oxide with superoxide
radical—is a short-lived oxidant species that is a potent inducer of cell death. Conditions in …

The many activities of metal ions in biology have stimulated the development of metal-based
therapeutics. Cisplatin, as one of the leading metal-based drugs, is widely used in treatment …

Oxidative stress has become widely viewed as an underlying condition in a number of
diseases, such as ischemia–reperfusion disorders, central nervous system disorders …

Accumulated evidence has shown that reactive oxygen species (ROS) are important
mediators of cell signaling events such as inflammatory reactions (superoxide) and the …

Despite numerous defenses, the brain is vulnerable to oxidative stress resulting from
ischemia/reperfusion. Excitotoxic stimulation of superoxide and nitric oxide production leads …

The threat of radiation-induced late normal tissue injury limits the dose of radiation that can
be delivered safely to cancer patients presenting with solid tumors. Tissue dysfunction and …

Ischemia-reperfusion injury (IRI), which describes the cell damage and death that occurs
after blood and oxygen are restored to ischemic or hypoxic tissue, is a significant factor …

Mitochondrial oxidative stress and dysfunction are contributing factors to various
neurological disorders. Recently, there has been increasing evidence supporting the …

Excessive production of free radicals is known to lead to cell injury in a variety of diseases,
such as cerebral ischemia. In this review, we describe some of the numerous studies that …