Advances and opportunities in malaria population genomics

DE Neafsey, AR Taylor, BL MacInnis - Nature Reviews Genetics, 2021 - nature.com
Almost 20 years have passed since the first reference genome assemblies were published
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …

malERA: an updated research agenda for malaria elimination and eradication

RN Rabinovich, C Drakeley, AA Djimde, BF Hall… - PLoS …, 2017 - journals.plos.org
Achieving a malaria-free world presents exciting scientific challenges as well as
overwhelming health, equity, and economic benefits. WHO and countries are setting …

Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1

A Amambua-Ngwa, KA Button-Simons, X Li… - Nature …, 2023 - nature.com
Malaria parasites break down host haemoglobin into peptides and amino acids in the
digestive vacuole for export to the parasite cytoplasm for growth: interrupting this process is …

Plasmodium Genomics and Genetics: New Insights into Malaria Pathogenesis, Drug Resistance, Epidemiology, and Evolution

X Su, KD Lane, L Xia, JM Sá… - Clinical microbiology …, 2019 - Am Soc Microbiol
Protozoan Plasmodium parasites are the causative agents of malaria, a deadly disease that
continues to afflict hundreds of millions of people every year. Infections with malaria …

Indels, structural variation, and recombination drive genomic diversity in Plasmodium falciparum

A Miles, Z Iqbal, P Vauterin, R Pearson… - Genome …, 2016 - genome.cshlp.org
The malaria parasite Plasmodium falciparum has a great capacity for evolutionary
adaptation to evade host immunity and develop drug resistance. Current understanding of …

Genomic analysis of local variation and recent evolution in Plasmodium vivax

RD Pearson, R Amato, S Auburn, O Miotto… - Nature …, 2016 - nature.com
The widespread distribution and relapsing nature of Plasmodium vivax infection present
major challenges for the elimination of malaria. To characterize the genetic diversity of this …

Understanding the ecology and evolution of host–parasite interactions across scales

RM Penczykowski, AL Laine… - Evolutionary …, 2016 - Wiley Online Library
Predicting the emergence, spread and evolution of parasites within and among host
populations requires insight to both the spatial and temporal scales of adaptation, including …

Single-cell transcriptomics reveals the complexity of the tumor microenvironment of treatment-naive osteosarcoma

Y Liu, W Feng, Y Dai, M Bao, Z Yuan, M He… - Frontiers in …, 2021 - frontiersin.org
Osteosarcoma (OS), which occurs most commonly in adolescents, is associated with a high
degree of malignancy and poor prognosis. In order to develop an accurate treatment for OS …

Highthroughput identification and diagnostics of pathogens and pests: overview and practical recommendations

L Tedersoo, R Drenkhan, S Anslan… - Molecular ecology …, 2019 - Wiley Online Library
Highthroughput identification technologies provide efficient tools for understanding the
ecology and functioning of microorganisms. Yet, these methods have been only rarely used …

[HTML][HTML] The molecular basis of antimalarial drug resistance in Plasmodium vivax

LE Buyon, B Elsworth, MT Duraisingh - International Journal for …, 2021 - Elsevier
Plasmodium vivax is the most geographically widespread cause of human malaria and is
responsible for the majority of cases outside of the African continent. While great progress …