Advances and opportunities in malaria population genomics
Almost 20 years have passed since the first reference genome assemblies were published
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …
malERA: an updated research agenda for malaria elimination and eradication
Achieving a malaria-free world presents exciting scientific challenges as well as
overwhelming health, equity, and economic benefits. WHO and countries are setting …
overwhelming health, equity, and economic benefits. WHO and countries are setting …
Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1
A Amambua-Ngwa, KA Button-Simons, X Li… - Nature …, 2023 - nature.com
Malaria parasites break down host haemoglobin into peptides and amino acids in the
digestive vacuole for export to the parasite cytoplasm for growth: interrupting this process is …
digestive vacuole for export to the parasite cytoplasm for growth: interrupting this process is …
Plasmodium Genomics and Genetics: New Insights into Malaria Pathogenesis, Drug Resistance, Epidemiology, and Evolution
Protozoan Plasmodium parasites are the causative agents of malaria, a deadly disease that
continues to afflict hundreds of millions of people every year. Infections with malaria …
continues to afflict hundreds of millions of people every year. Infections with malaria …
Indels, structural variation, and recombination drive genomic diversity in Plasmodium falciparum
The malaria parasite Plasmodium falciparum has a great capacity for evolutionary
adaptation to evade host immunity and develop drug resistance. Current understanding of …
adaptation to evade host immunity and develop drug resistance. Current understanding of …
Genomic analysis of local variation and recent evolution in Plasmodium vivax
The widespread distribution and relapsing nature of Plasmodium vivax infection present
major challenges for the elimination of malaria. To characterize the genetic diversity of this …
major challenges for the elimination of malaria. To characterize the genetic diversity of this …
Understanding the ecology and evolution of host–parasite interactions across scales
RM Penczykowski, AL Laine… - Evolutionary …, 2016 - Wiley Online Library
Predicting the emergence, spread and evolution of parasites within and among host
populations requires insight to both the spatial and temporal scales of adaptation, including …
populations requires insight to both the spatial and temporal scales of adaptation, including …
Single-cell transcriptomics reveals the complexity of the tumor microenvironment of treatment-naive osteosarcoma
Y Liu, W Feng, Y Dai, M Bao, Z Yuan, M He… - Frontiers in …, 2021 - frontiersin.org
Osteosarcoma (OS), which occurs most commonly in adolescents, is associated with a high
degree of malignancy and poor prognosis. In order to develop an accurate treatment for OS …
degree of malignancy and poor prognosis. In order to develop an accurate treatment for OS …
Highthroughput identification and diagnostics of pathogens and pests: overview and practical recommendations
Highthroughput identification technologies provide efficient tools for understanding the
ecology and functioning of microorganisms. Yet, these methods have been only rarely used …
ecology and functioning of microorganisms. Yet, these methods have been only rarely used …
[HTML][HTML] The molecular basis of antimalarial drug resistance in Plasmodium vivax
LE Buyon, B Elsworth, MT Duraisingh - International Journal for …, 2021 - Elsevier
Plasmodium vivax is the most geographically widespread cause of human malaria and is
responsible for the majority of cases outside of the African continent. While great progress …
responsible for the majority of cases outside of the African continent. While great progress …