Increases in cytosolic free Ca2+ ([Ca2+] i) represent a ubiquitous signalling mechanism that
controls a variety of cellular processes, including proliferation, metabolism and gene …

Plasma membrane (PM) ion channels contribute to virtually all basic cellular processes and
are also involved in the malignant phenotype of cancer cells. Here, we review the role of ion …

Cancer involves defects in the mechanisms underlying cell proliferation, death and
migration. Calcium ions are central to these phenomena, serving as major signalling agents …

Effective treatment as well as prognostic biomarker for malignant esophageal squamous cell
carcinoma (ESCC) is urgently needed. The present study was aimed at identifying …

Voltage-gated calcium channels (VGCCs) are well documented to play roles in cell
proliferation, migration, and apoptosis; however, whether VGCCs regulate the onset and …

Store‐operated calcium entry (SOCE) is the main Ca2+ influx pathway involved in
controlling proliferation of the human hepatoma cell lines Huh‐7 and HepG2. However, the …

Both increases in the basal cytosolic calcium concentration ([Ca2+] cyt) and [Ca2+] cyt
transients play major roles in cell cycle progression, cell proliferation and division. Calcium …

Ca2+ acts as a universal and versatile second messenger in the regulation of a myriad of
biological processes, including cell proliferation, differentiation, migration and apoptosis …

In non-excitable cells, Orai proteins represent the main channel for Store-Operated Calcium
Entry (SOCE), and also mediate various store-independent Calcium Entry (SICE) pathways …

The proliferation and motility of vascular endothelial cells (ECs) are critical steps in
angiogenesis and are strictly controlled by different extracellular signals. Among mitogens …