The placenta sits at the interface between the maternal and fetal vascular beds where it
mediates nutrient and waste exchange to enable in utero existence. Placental cells …

The placenta is the first organ to form during mammalian embryogenesis. Problems in its
formation and function underlie many aspects of early pregnancy loss and pregnancy …

Remodeling of the uterine vasculature by invasive extravillous trophoblasts (EVTs) is a
critical aspect of human placentation. Insufficient EVT invasion can lead to severe obstetrical …

The placenta of eutherian mammals is a remarkable biological structure. It is composed of
both zygote-derived and maternal cells, and mediates the complex interactions between the …

Recently, we and others have identified two human endogenous retroviruses that entered
the primate lineage 25–40 million years ago and that encode highly fusogenic retroviral …

Trophoblast cells of the placenta are established at the blastocyst stage and differentiate into
specialized subtypes after implantation 1, 2. In mice, the outer layer of the placenta consists …

Cells of the trophoblast lineage make up the epithelial compartment of the placenta, and
their rapid development is essential for the establishment and maintenance of pregnancy. A …

The human placental trophoblast cell can be classified as either a cytotrophoblast or a
syncytiotrophoblast. Cytotrophoblasts can function as stem cells for the development of the …

Villous cytotrophoblasts are epithelial stem cells of the early human placenta, able to
differentiate either into syncytiotrophoblasts in floating chorionic villi or extravillous …

The labyrinth of the rodent placenta contains villi that are the site of nutrient exchange
between mother and fetus. They are covered by three trophoblast cell types that separate …