Sepsis is a persistent systemic inflammatory condition involving multiple organ failures
resulting from a dysregulated immune response to infection, and one of the hallmarks of …

Background Maintaining the structural and functional integrity of the blood–brain barrier
(BBB) is vital for neuronal equilibrium and optimal brain function. Disruptions to BBB …

The blood-brain barrier (BBB), which is located at the interface between the central nervous
system (CNS) and the circulatory system, is instrumental in establishing and maintaining the …

Gut microbiota has emerged as an important environmental factor in the pathobiology of
multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous …

3K3A-Activated Protein C (APC) is a recombinant variant of the physiological anticoagulant
APC with pleiotropic cytoprotective properties albeit without the bleeding risks. The anti …

Sickle cell disease (SCD) is a hereditary hemoglobinopathy marked by hemolytic anemia
and vaso-occlusive events (VOEs). Chronic endothelial activation, inflammation, and …

Increased cerebrovascular amyloid-β (Aβ) deposition represents the main pathogenic
mechanisms characterizing Alzheimer's disease (AD) and cerebral amyloid angiopathy …

3K3A-Activated Protein C (APC) is a recombinant variant of the physiological anticoagulant
APC with cytoprotective properties and reduced bleeding risks. We studied the potential use …

Background Inflammation and coagulation are linked and pathogenic in neuroinflammatory
diseases. Protease-activated receptor 1 (PAR1) can be activated both by thrombin, inducing …

Repulsive guidance molecule‐a (RGMa) is a member of glycosylphosphatidylinositol‐(GPI‐)
anchored protein family, which has axon guidance function and is widely involved in the …