Understanding oncogenicity of cancer driver genes and mutations in the cancer genomics era
One of the key challenges of cancer biology is to catalogue and understand the somatic
genomic alterations leading to cancer. Although alternative definitions and search methods …
genomic alterations leading to cancer. Although alternative definitions and search methods …
Elevated somatic mutation burdens in normal human cells due to defective DNA polymerases
Mutation accumulation over time in normal somatic cells contributes to cancer development
and is proposed as a cause of ageing. DNA polymerases Pol ε and Pol δ replicate DNA with …
and is proposed as a cause of ageing. DNA polymerases Pol ε and Pol δ replicate DNA with …
[HTML][HTML] Open questions about cancer driver genes and mutations
One of the key challenges of cancer biology is to catalogue and understand the somatic
genomic alterations leading to cancer. Although alternative definitions and search methods …
genomic alterations leading to cancer. Although alternative definitions and search methods …
Somatic mutation in colorectal cancer: A window to disease pathogenesis
A D'Cruz - 2020 - ora.ox.ac.uk
Cancer has long been considered to be a disease driven by mutation. In recent years, this
theory has been updated to reflect increased understanding of the importance of additional …
theory has been updated to reflect increased understanding of the importance of additional …