Tapping into 5-HT3 Receptors to Modify Metabolic and Immune Responses
5-hydroxytryptamine type 3 (5-HT3) receptors are ligand gated ion channels, which clearly
distinguish their mode of action from the other G-protein coupled 5-HT or serotonin …
distinguish their mode of action from the other G-protein coupled 5-HT or serotonin …
Calcineurin Is a Universal Regulator of Vessel Function—Focus on Vascular Smooth Muscle Cells
A Nolze, S Matern, C Grossmann - Cells, 2023 - mdpi.com
Calcineurin, a serine/threonine phosphatase regulating transcription factors like NFaT and
CREB, is well known for its immune modulatory effects and role in cardiac hypertrophy …
CREB, is well known for its immune modulatory effects and role in cardiac hypertrophy …
[HTML][HTML] Calcineurin/NFAT signaling modulates pulmonary artery smooth muscle cell proliferation, migration and apoptosis in monocrotaline-induced pulmonary …
RL He, ZJ Wu, XR Liu, LX Gui, RX Wang… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Pulmonary arterial hypertension (PAH) is a severe and debilitating
disease characterized by remodeling of the pulmonary vessels, which is driven by excessive …
disease characterized by remodeling of the pulmonary vessels, which is driven by excessive …
LncRNA lnc‐ISG20 promotes renal fibrosis in diabetic nephropathy by inducing AKT phosphorylation through miR‐486‐5p/NFAT5
YR Duan, BP Chen, F Chen, SX Yang… - Journal of Cellular …, 2021 - Wiley Online Library
Long non‐coding RNA (lncRNA) lnc‐ISG20 has been found aberrantly up‐regulated in the
glomerular in the patients with diabetic nephropathy (DN). We aimed to elucidate the …
glomerular in the patients with diabetic nephropathy (DN). We aimed to elucidate the …
Circular RNA_0037128 aggravates high glucose-induced damage in HK-2 cells via regulation of microRNA-497-5p/nuclear factor of activated T cells 5 axis
T Feng, W Li, T Li, W Jiao, S Chen - Bioengineered, 2021 - Taylor & Francis
ABSTRACT Circular RNAs (CircRNAs) were reported to play vital roles in the progression of
DN. Herein, the action of circular RNA_0037128 (circ_0037128) was investigated in DN …
DN. Herein, the action of circular RNA_0037128 (circ_0037128) was investigated in DN …
Effects of ondansetron use on outcomes of acute kidney injury in critically ill patients: an analysis based on the MIMIC-IV database
L Tao, S Zhou, P Chang, S An - Journal of Critical Care, 2021 - Elsevier
Purpose Acute kidney injury (AKI) in intensive care units (ICUs) is a health priority with
limited treatment options. This study aimed to estimate the effects of ondansetron use on AKI …
limited treatment options. This study aimed to estimate the effects of ondansetron use on AKI …
Stachydrine hydrochloride suppresses phenylephrine-induced pathological cardiac hypertrophy by inhibiting the calcineurin/nuclear factor of activated T-cell …
J Zheng, J Tian, S Wang, P Hu, Q Wu, X Shan… - European Journal of …, 2020 - Elsevier
The calcineurin (CaN)/nuclear factor of activated T-cell (NFAT) signalling pathway plays an
important role in pathological cardiac hypertrophy. Here, we investigated the potential …
important role in pathological cardiac hypertrophy. Here, we investigated the potential …
Tropisetron inhibits high glucose-induced calcineurin/NFAT hypertrophic pathway in H9c2 myocardial cells
F Asadi, A Razmi, AR Dehpour… - Journal of Pharmacy and …, 2016 - academic.oup.com
Objectives Cardiomyocyte hypertrophy is an important structural feature of diabetic
cardiomyopathy. Calcineurin/nuclear factor of activated T-cell (NFAT) pathway plays a …
cardiomyopathy. Calcineurin/nuclear factor of activated T-cell (NFAT) pathway plays a …
Integrative omics analyses reveal epigenetic memory in diabetic renal cells regulating genes associated with kidney dysfunction
A Bansal, S Balasubramanian, S Dhawan, A Leung… - Diabetes, 2020 - Am Diabetes Assoc
Diabetic kidney disease (DKD) is a major complication of diabetes and the leading cause of
end-stage renal failure. Epigenetics has been associated with metabolic memory in which …
end-stage renal failure. Epigenetics has been associated with metabolic memory in which …
Tropisetron attenuates pancreas apoptosis in the STZ-induced diabetic rats: involvement of SIRT1/NF-κB signaling
Background Diabetes mellitus (DM) is one of the most common diseases in the worldwide.
Type 1 diabetes mellitus (T1DM) is characterized by insulin deficiency and beta cells …
Type 1 diabetes mellitus (T1DM) is characterized by insulin deficiency and beta cells …