[HTML][HTML] The gut microbiome in Alzheimer's disease: what we know and what remains to be explored

S Chandra, SS Sisodia, RJ Vassar - Molecular neurodegeneration, 2023 - Springer
Abstract Alzheimer's disease (AD), the most common cause of dementia, results in a
sustained decline in cognition. There are currently few effective disease modifying therapies …

[HTML][HTML] The obese brain: mechanisms of systemic and local inflammation, and interventions to reverse the cognitive deficit

V Salas-Venegas, RP Flores-Torres… - Frontiers in Integrative …, 2022 - frontiersin.org
Overweight and obesity are now considered a worldwide pandemic and a growing public
health problem with severe economic and social consequences. Adipose tissue is an organ …

[HTML][HTML] Alzheimer's disease and diabetes: Role of diet, microbiota and inflammation in preclinical models

MJ Carranza-Naval, M Vargas-Soria… - Biomolecules, 2021 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia. Epidemiological studies
show the association between AD and type 2 diabetes (T2DM), although the mechanisms …

[HTML][HTML] Microglia and BDNF at the crossroads of stressor related disorders: Towards a unique trophic phenotype

N Prowse, S Hayley - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Stressors ranging from psychogenic/social to neurogenic/injury to systemic/microbial can
impact microglial inflammatory processes, but less is known regarding their effects on …

[HTML][HTML] The effect of dietary fat consumption on Alzheimer's disease pathogenesis in mouse models

A Amelianchik, L Sweetland-Martin… - Translational Psychiatry, 2022 - nature.com
Alzheimer's disease (AD) is a fatal cognitive disorder with proteinaceous brain deposits,
neuroinflammation, cerebrovascular dysfunction, and extensive neuronal loss over time. AD …

From obesity to Alzheimer's disease through insulin resistance

S Terzo, A Amato, F Mulè - Journal of Diabetes and its Complications, 2021 - Elsevier
Alzheimer's disease is one of the most frequent forms of dementia. It is a progressive
neurodegenerative disease, characterized by presence of amyloid plaques and …

[HTML][HTML] Forsythoside B attenuates memory impairment and neuroinflammation via inhibition on NF-κB signaling in Alzheimer's disease

F Kong, X Jiang, R Wang, S Zhai, Y Zhang… - Journal of …, 2020 - Springer
Background Neuroinflammation is a principal element in Alzheimer's disease (AD)
pathogenesis, so anti-inflammation may be a promising therapeutic strategy. Forsythoside B …

[HTML][HTML] TREM-2-p38 MAPK signaling regulates neuroinflammation during chronic cerebral hypoperfusion combined with diabetes mellitus

J Zhang, Y Liu, Y Zheng, Y Luo, Y Du, Y Zhao… - Journal of …, 2020 - Springer
Background Diabetes mellitus (DM) and chronic cerebral hypoperfusion (CCH) are both risk
factors for cognitive impairment. However, whether DM and CCH can synergistically …

Inflammation: major denominator of obesity, Type 2 diabetes and Alzheimer's disease-like pathology?

M Kacířová, A Zmeškalová, L Kořínková… - Clinical …, 2020 - portlandpress.com
Adipose tissue is an active metabolic organ that contributes to processes such as energy
storage and utilization and to the production of a number of metabolic agents, such as …

Polysaccharide from Schisandra chinensis acts via LRP-1 to reverse microglia activation through suppression of the NF-κB and MAPK signaling

M Xu, J Wang, X Zhang, T Yan, B Wu, K Bi… - Journal of …, 2020 - Elsevier
Abstract Ethnopharmacological relevance Schisandra chinensis (Turcz.) Baill (S.
Chinensis), a traditional Chinese medicine frequently used in the traditional treatment of …