Multiorgan-on-a-chip (multi-OoC) platforms have great potential to redefine the way in which
human health research is conducted. After briefly reviewing the need for comprehensive …

Human organoids, self-organized and differentiated from homogenous pluripotent stem cells
(PSC), replicate the key structural and functional characteristics of their in vivo counterparts …

The vascularization of engineered tissues and organoids has remained a major unresolved
challenge in regenerative medicine. While multiple approaches have been developed to …

Predicting the effects of drugs before human clinical trials is at the heart of drug screening
and discovery processes. The cost of drug discovery is steadily increasing owing to the …

Tumor vasculature creates a hostile tumor microenvironment (TME) in vivo and nourishes
cancers, resulting in cancer progression and drug resistance. To mimic the biochemical and …

Organ-on-A-chip (OoAC) devices are miniaturized, functional, in vitro constructs that aim to
recapitulate the in vivo physiology of an organ using different cell types and extracellular …

Spheroids and organoids are important novel players in medical and life science research.
They are gradually replacing two-dimensional (2D) cell cultures. Indeed, three-dimensional …

The development of increasingly biomimetic human tissue analogs has been a long-
standing goal in two important biomedical applications: drug discovery and regenerative …

With recent progress in modeling liver organogenesis and regeneration, the lack of
vasculature is becoming the bottleneck in progressing our ability to model human hepatic …

Recreating human organ–level function in vitro is a rapidly evolving field that integrates
tissue engineering, stem cell biology, and microfluidic technology to produce 3D organoids …