Proper patterning of the nervous system requires that developing axons find appropriate
postsynaptic partners; this entails microns to meters of extension through an extracellular …

The complex patterns of neuronal wiring in the adult nervous system depend on a series of
guidance events during neural development that establish a framework on which functional …

An astonishing number of extracellular matrix glycoproteins are expressed in dynamic
patterns in the developing and adult nervous system. Neural stem cells, neurons, and glia …

A Drosophila homolog of human Down syndrome cell adhesion molecule (DSCAM), an
immunoglobulin superfamily member, was isolated by its affinity to Dock, an SH3/SH2 …

The guidance of developing axons in the nervous system is mediated partly by diffusible
chemoattractants secreted by axonal target cells. Netrins are chemoattractants for …

Netrins are secreted proteins that were first identified as guidance cues, directing cell and
axon migration during neural development. Subsequent findings have demonstrated that …

The robo gene in Drosophila was identified in a large-scale mutant screen for genes that
control the decision by axons to cross the CNS midline. In robo mutants, too many axons …

Cell adhesion is critical for the genesis and maintenance of both three-dimensional structure
and normal function in tissues. The biochemical entities mediating cell adhesion are …

Calcium-triggered fusion of synaptic vesicles and neurotransmitter release are fundamental
signalling steps in the central nervous system. It is generally assumed that fast transmitter …

The DCC (Deleted in colorectal cancer) gene was first identified as a candidate for a tumour-
suppressor gene on human chromosome 18q. More recently, in vitro studies in rodents have …