Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

Post-translational modifications of DNA and histones are epigenetic mechanisms, which
affect the chromatin structure, ultimately leading to gene expression changes. A number of …

Pemphigus vulgaris (PV) is a life-threatening skin disease in which autoantibodies against a
keratinocyte cell surface 130 kd glycoprotein, PV antigen (PVA), cause loss of cell-cell …

LANGERHANS cells (LC) are the principal accessory cells present in epidermis1. Because
LC have limited capacity for self-renewal2, epidermis is continually repopulated by as-yet …

Recessive lethal mutations in the fat locus of Drosophila cause hyperplastic, tumor-like
overgrowth of larval imaginal discs, defects in differentiation and morphogenesis, and death …

In patients with pemphigus vulgaris (PV), autoantibodies against desmoglein 3 (Dsg3)
cause loss of cell–cell adhesion of keratinocytes in the basal and immediate suprabasal …

Three proteins identified by quite different criteria in three different systems, the Drosophila
segment polarity gene armadillo, the human desmosomal protein plakoglobin, and the …

Complementary DNA cloning of the 130-kD pemphigus vulgaris (PV) autoantigen (PVA) has
indicated that it is a member of the cadherin family of Ca (2+)-dependent cell adhesion …

Desmosomes are intercellular adhesive junctions that anchor intermediate filaments at
membrane-associated plaques in adjoining cells, thereby forming a three-dimensional …

The Ca (2+)-dependent cell adhesion molecule uvomorulin is a member of the cadherin
gene family. Its cytoplasmic region complexes with structurally defined proteins termed …