2-Oxoglutarate (2OG)-dependent oxygenases (2OGXs) catalyze a remarkably diverse range
of oxidative reactions. In animals, these comprise hydroxylations and N-demethylations …

Endometriosis is a common gynecologic disorder with an enigmatic etiopathogenesis.
Although it has been proposed that endometriosis is a hormonal disease, an autoimmune …

COMPASS, the yeast homolog of the mammalian MLL complex, is a histone H3 lysine 4
(H3K4) methylase consisting of Set1 (KMT2) and seven other polypeptides, including …

The organization of the genome in the nucleus of a eukaryotic cell is fairly complex and
dynamic. Various features of the nuclear architecture, including compartmentalization of …

Cardiac hypertrophy and failure are accompanied by a reprogramming of gene expression
that involves transcription factors and chromatin remodeling enzymes. Little is known about …

This paper reviews the chemical and functional aspects of the posttranslational
modifications of proteins, which are achieved by the addition of various groups to the side …

Alterations in RNA levels are frequently reported in brain of subjects diagnosed with autism,
schizophrenia, depression, and other psychiatric diseases, but it remains unclear whether …

Histone H2B ubiquitination plays an important role in regulating chromatin organization
during gene transcription. It has been shown that RNF20/40 regulates H2B ubiquitination …

High-intensity interval training (HIIT) is emerging as a safe and effective means to combat
chronic diseases. The objective of this work was to perform a systematic review of the effect …

Gram-negative bacterial pathogens rely on the type III secretion system to inject virulence
proteins into host cells. These type III secreted “effector” proteins directly manipulate cellular …