The global obesity epidemic is a major contributor to chronic disease and disability in the
world today. Since the discovery of leptin in 1994, a multitude of studies have characterized …

Macrophages represent a heterogeneous cell population and are known to display a
remarkable plasticity. In response to distinct micro-environmental stimuli, eg, tumor stroma …

Microglia are resident macrophage-like immune cells in the central nervous system (CNS)
and play a vital role in both physiological and pathological conditions, including restoring …

CCRL2 is a seven-transmembrane domain receptor that belongs to the chemokine receptor
family. At difference from other members of this family, CCRL2 does not promote chemotaxis …

Macrophages are the key regulator of T-cell responses depending on their activation state.
CC motif chemokine receptor-like 2 (CCRL2), a nonsignaling atypical receptor originally …

Inflammatory reactions occurring in the central nervous system (CNS), known as
neuroinflammation, are key components of the pathogenic mechanisms underlying several …

Chemerin, an adipokine, has been reported to reduce the production of pro-inflammatory
cytokines and neutrophil infiltration. This study investigated the role of Chemerin and its …

CCRL2 is a 7-transmembrane domain receptor that shares structural and functional
similarities with the family of atypical chemokine receptors (ACKRs). CCRL2 is upregulated …

Apical periodontitis (AP) is an acute or chronic inflammatory disease caused by complex
interactions between infected root canal and host immune system. It results in the induction …

Multiple sclerosis (MS) is an immune-mediated and neurodegenerative disorder that results
in inflammation and demyelination of the central nervous system (CNS). MS symptoms …