[HTML][HTML] The future of pharmaceutical manufacturing sciences

J Rantanen, J Khinast - Journal of pharmaceutical sciences, 2015 - Elsevier
The entire pharmaceutical sector is in an urgent need of both innovative technological
solutions and fundamental scientific work, enabling the production of highly engineered …

Recent progress of continuous crystallization

T Wang, H Lu, J Wang, Y Xiao, Y Zhou, Y Bao… - Journal of industrial and …, 2017 - Elsevier
Continuous crystallization has always been a hot topic in industrial crystallization. Many
efforts have been made to improve the continuous crystallization, either by designing novel …

Large-scale CFD–DEM simulations of fluidized granular systems

D Jajcevic, E Siegmann, C Radeke… - Chemical Engineering …, 2013 - Elsevier
The combination of Computational Fluid Dynamics (CFD) and Discrete Element Model
(DEM) is a powerful tool for studying fluidized particulate systems and granular flows. In …

An integrated approach for dynamic flowsheet modeling and sensitivity analysis of a continuous tablet manufacturing process

F Boukouvala, V Niotis, R Ramachandran… - Computers & chemical …, 2012 - Elsevier
Manufacturing of powder-based products is a focus of increasing research in the recent
years. The main reason is the lack of predictive process models connecting process …

Modeling segregation in granular flows

PB Umbanhowar, RM Lueptow… - Annual review of …, 2019 - annualreviews.org
Accurate continuum models of flow and segregation of dense granular flows are now
possible. This is the result of extensive comparisons, over the last several years, of computer …

Modeling of particulate processes for the continuous manufacture of solid-based pharmaceutical dosage forms

AJ Rogers, A Hashemi, MG Ierapetritou - Processes, 2013 - mdpi.com
The objective of this work is to present a review of computational tools and models for
pharmaceutical processes, specifically those for the continuous manufacture of solid dosage …

Effect of spiral blade geometry on 3D-printed concrete rheological properties and extrudability using discrete element modeling

P Zhi, YC Wu, Q Yang, X Kong, J Xiao - Automation in Construction, 2022 - Elsevier
Sizes and shapes of spiral blades have a great influence on 3D printable concrete
construction. This study is presented to answer two research questions: How does spiral …

A particle‐scale index in the quantification of mixing of particles

GR Chandratilleke, AB Yu, J Bridgwater… - AIChE …, 2012 - Wiley Online Library
Discrete element method (DEM) is a useful tool for obtaining details of mixing processes at a
particle scale. It has been shown to satisfactorily describe the flow structure developed in …

The effect of the number of impeller blades on granular flow in a bladed mixer

V Boonkanokwong, B Remy, JG Khinast, BJ Glasser - Powder technology, 2016 - Elsevier
Simulations of granular flow of monodisperse, cohesionless spherical glass beads in a
cylindrical bladed mixer agitated by an impeller were performed using the discrete element …

Polydisperse granular flows in a bladed mixer: Experiments and simulations of cohesionless spheres

B Remy, JG Khinast, BJ Glasser - Chemical Engineering Science, 2011 - Elsevier
The flow and segregation of polydisperse, spherical particle mixtures in a bladed mixer was
investigated using experimental and computational techniques. Discrete element …