Background: Among head and neck squamous cell carcinomas (HNSCCs), hypopharyngeal
squamous cell carcinoma (HPSCC) has the worst prognosis. Iron metabolism, which plays a …

Objective Alcohol consumption, smoking, and excess weight independently increase the risk
of morbidity/mortality. Less is known about how they interact. This research aims to quantify …

Background Having emerged as the most abundant posttranscriptional internal mRNA
modification in eukaryotes, N6‐methyladenosine (m6A) has attracted tremendous scientific …

Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers, yet
the molecular mechanisms underlying its onset and development have not yet been fully …

Hypopharyngeal squamous cell carcinoma (HPSCC) is one of the most aggressive cancers
and is notorious for its extremely poor prognosis. However, very few molecular biological …

Background Despite reports of a link between human papillomavirus (HPV) infection and
mechanistic target of rapamycin (mTOR) signaling activation, the role of the mTOR pathway …

In recurrent or metastatic head and neck squamous cell carcinoma (R/M-HNSCC), survival
outcomes are significantly better in patients who receive anti-programmed cell death-1 (PD …

Objective Head and neck cancer (HNC) is a prevalent and complex group of malignancies
with increasing incidence globally. Alcohol dehydrogenases (ADHs) play a crucial role in …

Purpose To evaluate the prognostic significance of DNA excision repair gene
polymorphisms, excision repair cross-complementation group 1 (ERCC1) and X-ray repair …

Background Aldehyde dehydrogenase‐2 (ALDH2) plays an important role in the alcohol
detoxification and acetaldehyde metabolism. Published studies have demonstrated some …