Proteins are responsible for the occurrence and treatment of many diseases, and therefore
protein sequencing will revolutionize proteomics and clinical diagnostics. Biological …

Proteins are the structural elements and machinery of cells responsible for a functioning
biological architecture and homeostasis. Advances in nanotechnology are catalyzing key …

Efforts to sequence single protein molecules in nanopores,,,–have been hampered by the
lack of techniques with sufficient sensitivity to discern the subtle molecular differences …

There are still unmet needs in finding new technologies for biomedical diagnostic and
industrial applications. A technology allowing the analysis of size and sequence of short …

The reconstitution of channel-forming proteins into planar lipid bilayers enables their
functional characterization at very low (sometimes below attomolar) concentrations. We …

Biological membranes provide a physical boundary that separates the inside and outside of
a cell or organelle. They also mediate signal transduction and transport of various molecules …

Nanopore-based sensing is a powerful technique for the detection of diverse organic and
inorganic molecules, long-read sequencing of nucleic acids, and single-molecule analyses …

Previously we showed that the protein unfoldase ClpX could facilitate translocation of
individual proteins through the α-hemolysin nanopore. This results in ionic current …

Transport of molecules through biological membranes is a fundamental process in biology,
facilitated by selective channels and general pores. The architecture of some outer …

Resistive pulse nanopore sensing enables label‐free single‐molecule analysis of a wide
range of analytes. An increasing number of studies have demonstrated the feasibility and …