Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Carcinogenesis cannot be explained only by genetic alterations, but also involves
epigenetic processes. Modification of histones by acetylation plays a key role in epigenetic …

Autophagy is an evolutionarily conserved catabolic mechanism, by which eukaryotic cells
recycle or degrades internal constituents through membrane-trafficking pathway. Thus …

Epigenetic aberrations, which are recognized as key drivers of several human diseases, are
often caused by genetic defects that result in functional deregulation of epigenetic proteins …

Simple Summary Beyond mutations, epigenetic changes have been described as drivers for
cancer as well. While leaving the overall DNA structure intact, they can be responsible for …

Kaempferol, a flavonoid, found in traditional medicine, fruits, and vegetables, and an HDAC
inhibitor, is a powerful anti-cancer reagent against various cancer cell lines. However …

Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …

Despite advances in neurosurgical techniques and radio-/chemotherapy, the treatment of
brain tumors remains a challenge. This is particularly true for the most frequent and fatal …

The Atg1/ULK1 complex plays a central role in starvation-induced autophagy, integrating
signals from upstream sensors such as MTOR and AMPK and transducing them to the …

Autophagy is a conserved process by which cytoplasmic components are degraded by the
lysosome. It is commonly seen as a cytoplasmic event and, until now, nuclear events were …