Acute kidney injury (AKI) is now recognized as a heterogeneous syndrome that not only
affects acute morbidity and mortality, but also a patient's long-term prognosis. In this …

Objective: Fluid administration in combination with the increase in vasopermeability induced
by critical illness often results in significant fluid overload in critically ill patients. Recent …

Background Early aggressive hydration is widely recommended for the management of
acute pancreatitis, but evidence for this practice is limited. Methods At 18 centers, we …

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

Background Intravenous fluids are recommended for the treatment of patients who are in
septic shock, but higher fluid volumes have been associated with harm in patients who are …

Background Intravenous fluids and vasopressor agents are commonly used in early
resuscitation of patients with sepsis, but comparative data for prioritizing their delivery are …

Acute kidney injury (AKI) is a commonly encountered syndrome associated with various
aetiologies and pathophysiological processes leading to decreased kidney function. In …

In patients with septic shock, the administration of fluids during initial hemodynamic
resuscitation remains a major therapeutic challenge. We are faced with many open …

Acute kidney injury (AKI) and sepsis carry consensus definitions. The simultaneous
presence of both identifies septic AKI. Septic AKI is the most common AKI syndrome in ICU …

Background It is unknown whether a conservative approach to fluid administration or
deresuscitation (active removal of fluid using diuretics or renal replacement therapy) is …