The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …

Neuroblastoma is a neural crest derived malignancy of the peripheral nervous system and is
the most common and deadliest tumor of infancy. It is characterized by clinical heterogeneity …

Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by
145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating …

Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis,,.
We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and found an …

Opisthorchis viverrini–related cholangiocarcinoma (CCA), a fatal bile duct cancer, is a major
public health concern in areas endemic for this parasite. We report here whole-exome …

Axons are guided along specific pathways by attractive and repulsive cues in the
extracellular environment. Genetic and biochemical studies have led to the identification of …

The sequencing of complete genomes provides a list that includes the proteins responsible
for cellular regulation. However, this does not immediately reveal what these proteins do …

Electrical stimulation (ES) has been applied in cell culture system to enhance neural stem
cell (NSC) proliferation, neuronal differentiation, migration, and integration. According to the …

Vascular injury triggers dedifferentiation and cytoskeletal remodeling of smooth muscle cells
(SMCs), culminating in vessel occlusion. Serum response factor (SRF) and its coactivator …

Wiskott–Aldrich syndrome protein (WASP) and WASP-family verprolin-homologous protein
(WAVE) family proteins are scaffolds that link upstream signals to the activation of the …