Chronic obstructive pulmonary disease (COPD) is a major global health problem that is
poorly treated by current therapies as it has proved difficult to treat the underlying …

COPD is a significant cause of morbidity and mortality. In some patients with COPD,
eosinophils contribute to inflammation that promotes airway obstruction; approximately a …

Background The peripheral blood eosinophil count might help identify those patients with
chronic obstructive pulmonary disease (COPD) who will experience fewer exacerbations …

Background Previous studies have highlighted a relationship between reduction in rate of
exacerbations with therapies containing inhaled corticosteroids (ICS) and baseline blood …

Rationale: Post hoc analyses suggest that blood eosinophils have potential as a predictive
biomarker of inhaled corticosteroid efficacy in the management of chronic obstructive …

In patients with COPD, there is controversy regarding the association of blood eosinophil
(Eos) levels with 1) exacerbation frequency and 2) the effect of inhaled corticosteroids for …

Background Asthma-COPD overlap (ACO) is a term that encompasses patients with
characteristics of two conditions, smoking asthmatics or COPD patients with asthma-like …

Chronic airflow obstruction affects a wide range of airway diseases, the most frequent of
which are asthma, COPD, and bronchiectasis; they are clearly identifiable in their extremes …

Background COPD is a highly heterogeneous disease. Potential biomarkers to identify
patients with COPD who will derive the greatest benefit from inhaled corticosteroid (ICS) …

Background and objective Airway inflammation accompanying exacerbations varies among
individuals with some having neutrophilic, while others showing eosinophilic inflammation …