AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …

Abstract β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors offer the
potential of disease-modifying treatment for Alzheimer's disease (AD). Since 2014, major …

Introduction Inhibition of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) has
been extensively pursued as potential disease-modifying treatment for Alzheimer's disease …

Introduction: Alzheimer's disease (AD) is an intensifying neurodegenerative illness due to its
irreversible nature. Identification of β128; site Amyloid Precursor Protein (APP) cleaving en …

BACE1 is responsible for the first step in APP proteolysis, leading to toxic Aβ production, and
has been indicated to play a key role in the pathogenesis of Alzheimer's disease. The …

Malaria is a life-threatening infectious disease caused by Plasmodium parasites.
Plasmepsins (proteolytic enzymes of the parasite) have been considered as promising …

Background: Alzheimer disease (AD) can be considered as the most common age related
neurodegenerative disorder and also an important cause of death in elderly patients. A …

Pepsin-like aspartic proteases (PAPs) are a class of aspartic proteases which shares
tremendous structural similarity with human pepsin. One of the key structural features of …

The flexibility of β hairpin structure known as the flap plays a key role in catalytic activity and
substrate intake in pepsin-like aspartic proteases. Most of these enzymes share structural …

Heat shock protein 90 (Hsp90) is a crucial component in carcinogenesis and serves as a
molecular chaperone that facilitates protein maturation whilst protecting cells against …