Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …

Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial
pathophysiological process that cannot yet be recapitulated in a single in vitro model …

Systems Toxicology is the integration of classical toxicology with quantitative analysis of
large networks of molecular and functional changes occurring across multiple levels of …

The liver is not only the largest organ in the body but also the one playing one of the most
important role in the human metabolism as it is in charge of transforming toxic substances in …

Digital twins are defined as digital replicas of processes, systems or devices developed to
foster deeper understanding and prediction. While the concept of digital twins has largely …

Hepatic toxicity is a key concern for novel pharmaceutical drugs since it is difficult to
anticipate in preclinical models, and it can originate from pharmacologically unrelated drug …

Tolvaptan is a selective vasopressin V2 receptor antagonist, approved in several countries
for the treatment of hyponatremia and autosomal dominant polycystic kidney disease …

Massive investment and technological advances in the collection of extensive and
longitudinal information on thousands of Alzheimer patients results in large amounts of data …

In clinical trials of cannabidiol (CBD) for the treatment of seizures in patients with Dravet
syndrome, Lennox–Gastaut syndrome, and tuberous sclerosis complex, elevations in serum …

From the more than 100 liver diseases described, many of those with high incidence rates
manifest themselves by histopathological changes, such as hepatitis, alcoholic liver disease …