The origins of the major classes of current anti-emetics are examined. Serendipity is a
recurrent theme in discovery of their anti-emetic properties and repurposing from one …

Nausea is an uneasy feeling in the stomach while vomiting refers to the forceful expulsion of
gastric contents. Chronic nausea and vomiting represent a diverse array of disorders …

Gastroparesis (GP) is a disorder of gastric functions that is defined by objective delayed
gastric emptying in the absence of mechanical obstruction. This disease is characterized by …

Background Drugs which can inhibit nausea/vomiting and/or increase gastric emptying are
used to treat gastroparesis, mostly 'off‐label'. Within each category, they act at different …

Introduction Gastroparesis symptoms can be severe and debilitating. Many patients do not
respond to currently available treatments. Mirtazapine has been shown in case reports to …

Background Ontologies are widely used across biology and biomedicine for the annotation
of databases. Ontology development is often a manual, time-consuming, and expensive …

Background Disturbances of gastric motor function of functional dyspepsia (FD) have been
implicated in the pathogenesis of the symptoms, and hence, motility modifying agents are …

Chronic nausea is a highly prevalent, bothersome, and difficult-to-treat symptom among
adolescents. When chronic nausea presents as the predominant symptom and is not …

Functional nausea is a condition that severely impairs the quality of life of affected
individuals. Only recently, it has been added to the pediatric list of disorders of gut-brain …

Materials and Methods: Solid-meal gastric-emptying study using radiolabeled meal was
performed in 28 patients suffering from cancer anorexia once at baseline and repeated after …