[HTML][HTML] Autophagy and apoptosis dysfunction in neurodegenerative disorders
Autophagy and apoptosis are basic physiologic processes contributing to the maintenance
of cellular homeostasis. Autophagy encompasses pathways that target long-lived cytosolic …
of cellular homeostasis. Autophagy encompasses pathways that target long-lived cytosolic …
Implications of phosphoinositide 3-kinase-Akt (PI3K-Akt) pathway in the pathogenesis of Alzheimer's disease
Alzheimer's disease (AD) is the foremost type of dementia that afflicts considerable morbidity
and mortality in aged population. Several transcription molecules, pathways, and molecular …
and mortality in aged population. Several transcription molecules, pathways, and molecular …
Oxidant/antioxidant imbalance in Alzheimer's disease: therapeutic and diagnostic prospects
J Wojsiat, KM Zoltowska… - Oxidative medicine …, 2018 - Wiley Online Library
Alzheimer's disease (AD) is the most common cause of dementia and a great
socioeconomic burden in the aging society. Compelling evidence demonstrates that …
socioeconomic burden in the aging society. Compelling evidence demonstrates that …
Mitochondrial diseases of the brain
RK Chaturvedi, MF Beal - Free Radical Biology and Medicine, 2013 - Elsevier
Neurodegenerative disorders are debilitating diseases of the brain, characterized by
behavioral, motor and cognitive impairments. Ample evidence underpins mitochondrial …
behavioral, motor and cognitive impairments. Ample evidence underpins mitochondrial …
Linking the amyloid, tau, and mitochondrial hypotheses of Alzheimer's disease and identifying promising drug targets
Z Fišar - Biomolecules, 2022 - mdpi.com
Damage or loss of brain cells and impaired neurochemistry, neurogenesis, and synaptic and
nonsynaptic plasticity of the brain lead to dementia in neurodegenerative diseases, such as …
nonsynaptic plasticity of the brain lead to dementia in neurodegenerative diseases, such as …
Quinones as neuroprotective agents
Á Cores, N Carmona-Zafra, J Clerigué, M Villacampa… - Antioxidants, 2023 - mdpi.com
Quinones can in principle be viewed as a double-edged sword in the treatment of
neurodegenerative diseases, since they are often cytoprotective but can also be cytotoxic …
neurodegenerative diseases, since they are often cytoprotective but can also be cytotoxic …
A review on mitochondrial restorative mechanism of antioxidants in Alzheimer's disease and other neurological conditions
A Kumar, A Singh - Frontiers in pharmacology, 2015 - frontiersin.org
Neurodegenerative diseases are intricate in nature because of the involvement of the
multiple pathophysiological events including mitochondrial dysfunction, neuroinflammation …
multiple pathophysiological events including mitochondrial dysfunction, neuroinflammation …
Coenzyme Q10 and dementia: a systematic review
FJ Jiménez-Jiménez, H Alonso-Navarro… - Antioxidants, 2023 - mdpi.com
It is well known that coenzyme Q10 (CoQ10) has important antioxidant properties. Because
one of the main mechanisms involved in the pathogenesis of Alzheimer's disease (AD) and …
one of the main mechanisms involved in the pathogenesis of Alzheimer's disease (AD) and …
Cellular consequences of coenzyme Q10 deficiency in neurodegeneration of the retina and brain
Coenzyme Q10 (CoQ10) is a ubiquitous cofactor in the body, operating in the inner
mitochondrial membrane, where it plays a vital role in the generation of adenosine …
mitochondrial membrane, where it plays a vital role in the generation of adenosine …
Mitochondrial Coenzyme Q Protects Sepsis‐Induced Acute Lung Injury by Activating PI3K/Akt/GSK‐3β/mTOR Pathway in Rats
R Li, T Ren, J Zeng - BioMed research international, 2019 - Wiley Online Library
The aim of our study was to assess the effects of mitochondrial coenzyme Q (MitoQ) on
sepsis‐induced acute lung injury (ALI) and investigate its possible mechanisms. The cecal …
sepsis‐induced acute lung injury (ALI) and investigate its possible mechanisms. The cecal …