[HTML][HTML] Autophagy and apoptosis dysfunction in neurodegenerative disorders

S Ghavami, S Shojaei, B Yeganeh, SR Ande… - Progress in …, 2014 - Elsevier
Autophagy and apoptosis are basic physiologic processes contributing to the maintenance
of cellular homeostasis. Autophagy encompasses pathways that target long-lived cytosolic …

Implications of phosphoinositide 3-kinase-Akt (PI3K-Akt) pathway in the pathogenesis of Alzheimer's disease

M Kumar, N Bansal - Molecular neurobiology, 2022 - Springer
Alzheimer's disease (AD) is the foremost type of dementia that afflicts considerable morbidity
and mortality in aged population. Several transcription molecules, pathways, and molecular …

Oxidant/antioxidant imbalance in Alzheimer's disease: therapeutic and diagnostic prospects

J Wojsiat, KM Zoltowska… - Oxidative medicine …, 2018 - Wiley Online Library
Alzheimer's disease (AD) is the most common cause of dementia and a great
socioeconomic burden in the aging society. Compelling evidence demonstrates that …

Mitochondrial diseases of the brain

RK Chaturvedi, MF Beal - Free Radical Biology and Medicine, 2013 - Elsevier
Neurodegenerative disorders are debilitating diseases of the brain, characterized by
behavioral, motor and cognitive impairments. Ample evidence underpins mitochondrial …

Linking the amyloid, tau, and mitochondrial hypotheses of Alzheimer's disease and identifying promising drug targets

Z Fišar - Biomolecules, 2022 - mdpi.com
Damage or loss of brain cells and impaired neurochemistry, neurogenesis, and synaptic and
nonsynaptic plasticity of the brain lead to dementia in neurodegenerative diseases, such as …

Quinones as neuroprotective agents

Á Cores, N Carmona-Zafra, J Clerigué, M Villacampa… - Antioxidants, 2023 - mdpi.com
Quinones can in principle be viewed as a double-edged sword in the treatment of
neurodegenerative diseases, since they are often cytoprotective but can also be cytotoxic …

A review on mitochondrial restorative mechanism of antioxidants in Alzheimer's disease and other neurological conditions

A Kumar, A Singh - Frontiers in pharmacology, 2015 - frontiersin.org
Neurodegenerative diseases are intricate in nature because of the involvement of the
multiple pathophysiological events including mitochondrial dysfunction, neuroinflammation …

Coenzyme Q10 and dementia: a systematic review

FJ Jiménez-Jiménez, H Alonso-Navarro… - Antioxidants, 2023 - mdpi.com
It is well known that coenzyme Q10 (CoQ10) has important antioxidant properties. Because
one of the main mechanisms involved in the pathogenesis of Alzheimer's disease (AD) and …

Cellular consequences of coenzyme Q10 deficiency in neurodegeneration of the retina and brain

H Manzar, D Abdulhussein, TE Yap… - International Journal of …, 2020 - mdpi.com
Coenzyme Q10 (CoQ10) is a ubiquitous cofactor in the body, operating in the inner
mitochondrial membrane, where it plays a vital role in the generation of adenosine …

Mitochondrial Coenzyme Q Protects Sepsis‐Induced Acute Lung Injury by Activating PI3K/Akt/GSK‐3β/mTOR Pathway in Rats

R Li, T Ren, J Zeng - BioMed research international, 2019 - Wiley Online Library
The aim of our study was to assess the effects of mitochondrial coenzyme Q (MitoQ) on
sepsis‐induced acute lung injury (ALI) and investigate its possible mechanisms. The cecal …