Experimental models of Alzheimer's disease (AD) are critical to gaining a better
understanding of pathogenesis and to assess the potential of novel therapeutic approaches …

Microglia are the primary immune cells of the central nervous system that help nourish and
support neurons, clear debris, and respond to foreign stimuli. Greatly impacted by their …

The hippocampal-entorhinal system supports cognitive functions, has lifelong neurogenic
capabilities in many species, and is selectively vulnerable to Alzheimer's disease. To …

Receptor for advanced glycation end products (RAGE) is a receptor of the immunoglobulin
super family that plays various important roles under physiological and pathological …

Alzheimer's disease (AD) is one of the looming health crises of the near future. Increasing
lifespans and better medical treatment for other conditions mean that the prevalence of this …

The great apes (chimpanzees, bonobos, gorillas, and orangutans) are our closest relatives.
Despite the many similarities, there are significant differences in aging among apes …

Over 5 million Americans and 50 million individuals worldwide are living with Alzheimer's
disease (AD). The progressive dementia associated with AD currently has no cure. Although …

Neurodegenerative diseases present a major and increasing burden in the societies
worldwide. With aging populations, the prevalence of neurodegenerative diseases is …

Human life expectancy has increased over the past few centuries, and the incidence of
dementia in the older population is also projected to continue to rise. Neurodegenerative …

Alzheimer's disease (AD) is a uniquely human brain disorder characterized by the
accumulation of amyloid-beta protein (Aβ) into extracellular plaques, neurofibrillary tangles …