Sex differences in the epidemiology, clinical features, and pathophysiology of migraine

KG Vetvik, EA MacGregor - The Lancet Neurology, 2017 - thelancet.com
Migraine is two to three times more prevalent in women than men, and women report a
longer attack duration, increased risk of headache recurrence, greater disability, and a …

Hormonal influences in migraine—interactions of oestrogen, oxytocin and CGRP

DN Krause, K Warfvinge, KA Haanes… - Nature Reviews …, 2021 - nature.com
Migraine is ranked as the second highest cause of disability worldwide and the first among
women aged 15–49 years. Overall, the incidence of migraine is threefold higher among …

[HTML][HTML] Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

H Hautakangas, BS Winsvold, SE Ruotsalainen… - Nature …, 2022 - nature.com
Migraine affects over a billion individuals worldwide but its genetic underpinning remains
largely unknown. Here, we performed a genome-wide association study of 102,084 …

Migraine: multiple processes, complex pathophysiology

R Burstein, R Noseda, D Borsook - Journal of Neuroscience, 2015 - Soc Neuroscience
Migraine is a common, multifactorial, disabling, recurrent, hereditary neurovascular
headache disorder. It usually strikes sufferers a few times per year in childhood and then …

Gender-related differences in migraine

G Allais, G Chiarle, S Sinigaglia, G Airola… - Neurological …, 2020 - Springer
Migraine is considered mostly a woman's complaint, even if it affects also men.
Epidemiological data show a higher incidence of the disease in women, starting from …

Male and female sex hormones in primary headaches

Z Delaruelle, TA Ivanova, S Khan, A Negro… - The journal of Headache …, 2018 - Springer
Background The three primary headaches, tension-type headache, migraine and cluster
headache, occur in both genders, but all seem to have a sex-specific prevalence. These …

Role of estrogens in menstrual migraine

RE Nappi, L Tiranini, S Sacco, E De Matteis, R De Icco… - Cells, 2022 - mdpi.com
Migraine is a major neurological disorder affecting one in nine adults worldwide with a
significant impact on health care and socioeconomic systems. Migraine is more prevalent in …

Prolactin and oxytocin: potential targets for migraine treatment

AK Szewczyk, S Ulutas, T Aktürk, L Al-Hassany… - The Journal of …, 2023 - Springer
Migraine is a severe neurovascular disorder of which the pathophysiology is not yet fully
understood. Besides the role of inflammatory mediators that interact with the …

Sex and gender considerations in episodic migraine

SR Ahmad, N Rosendale - Current pain and headache reports, 2022 - Springer
Abstract Purpose of Review We seek to update readers on recent advances in our
understanding of sex and gender in episodic migraine with a two part series. In part 1, we …

Dysregulation of serum prolactin links the hypothalamus with female nociceptors to promote migraine

M Watanabe, CM Kopruszinski, A Moutal, D Ikegami… - Brain, 2022 - academic.oup.com
Migraine headache results from activation of meningeal nociceptors, however, the
hypothalamus is activated many hours before the emergence of pain. How hypothalamic …