The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …

In the ancient anaerobic environment, ferrous iron (Fe2+) was one of the first metal
cofactors. Oxygenation of the ancient world challenged bacteria to acquire the insoluble …

Protein metal-coordination sites are richly varied and exquisitely attuned to their inorganic
partners, yet many metalloproteins still select the wrong metals when presented with …

Control of metal homeostasis is essential for life in all kingdoms. In most prokaryotic
organisms the FUR (ferric uptake regulator) family of transcriptional regulators is involved in …

Recent evidence shows that mycobacteria have developed novel and specialized secretion
systems for the transport of extracellular proteins across their hydrophobic, and highly …

The transition or d-block metal ions manganese, iron, cobalt, nickel, copper, zinc and to a
more specialized degree molybdenum, tungsten, and vanadium have been shown to be …

Metals are required cofactors for numerous fundamental processes that are essential to both
pathogen and host. They are coordinated in enzymes responsible for DNA replication and …

Bacteria live in environments that are subject to rapid changes in the availability of the
nutrients that are necessary to provide energy and biosynthetic intermediates for the …

Mycobacterium marinum, a ubiquitous pathogen of fish and amphibia, is a near relative of
Mycobacterium tuberculosis, the etiologic agent of tuberculosis in humans. The genome of …

Mycobacterium tuberculosis (Mtb) encodes five type VII secretion systems (T7SS),
designated ESX-1–ESX-5, that are critical for growth and pathogenesis. The best …