APOE2: protective mechanism and therapeutic implications for Alzheimer's disease
Investigations of apolipoprotein E (APOE) gene, the major genetic risk modifier for
Alzheimer's disease (AD), have yielded significant insights into the pathogenic mechanism …
Alzheimer's disease (AD), have yielded significant insights into the pathogenic mechanism …
Epidemiology of age-related macular degeneration (AMD): associations with cardiovascular disease phenotypes and lipid factors
KL Pennington, MM DeAngelis - Eye and vision, 2016 - Springer
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in
adults over 50 years old. Genetic, epidemiological, and molecular studies are beginning to …
adults over 50 years old. Genetic, epidemiological, and molecular studies are beginning to …
Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma
Summary The apolipoprotein E4 (APOE4) allele is associated with an increased risk of
Alzheimer disease and a decreased risk of glaucoma, but the underlying mechanisms …
Alzheimer disease and a decreased risk of glaucoma, but the underlying mechanisms …
[PDF][PDF] Microglial function is distinct in different anatomical locations during retinal homeostasis and degeneration
Microglia from different nervous system regions are molecularly and anatomically distinct,
but whether they also have different functions is unknown. We combined lineage tracing …
but whether they also have different functions is unknown. We combined lineage tracing …
Pleiotropy in complex traits: challenges and strategies
Genome-wide association studies have identified many variants that each affects multiple
traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders …
traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders …
Risk factors and biomarkers of age-related macular degeneration
NG Lambert, H ElShelmani, MK Singh… - Progress in retinal and …, 2016 - Elsevier
A biomarker can be a substance or structure measured in body parts, fluids or products that
can affect or predict disease incidence. As age-related macular degeneration (AMD) is the …
can affect or predict disease incidence. As age-related macular degeneration (AMD) is the …
Seven new loci associated with age-related macular degeneration
Nature genetics, 2013 - nature.com
Age-related macular degeneration (AMD) is a common cause of blindness in older
individuals. To accelerate the understanding of AMD biology and help design new …
individuals. To accelerate the understanding of AMD biology and help design new …
Corneal transplantation
DTH Tan, JKG Dart, EJ Holland, S Kinoshita - The Lancet, 2012 - thelancet.com
Corneal transplantation or keratoplasty has developed rapidly in the past 10 years.
Penetrating keratoplasty, a procedure consisting of full-thickness replacement of the cornea …
Penetrating keratoplasty, a procedure consisting of full-thickness replacement of the cornea …
Mechanisms of age‐related macular degeneration and therapeutic opportunities
M van Lookeren Campagne, J LeCouter… - The Journal of …, 2014 - Wiley Online Library
As the age of the population increases in many nations, age‐related degenerative diseases
pose significant socioeconomic challenges. One of the key degenerative diseases that …
pose significant socioeconomic challenges. One of the key degenerative diseases that …
Age-related macular degeneration
Age-related macular degeneration is a major cause of blindness worldwide. With ageing
populations in many countries, more than 20% might have the disorder. Advanced age …
populations in many countries, more than 20% might have the disorder. Advanced age …