Emerging building blocks for medicinal chemistry: recent synthetic advances
OO Grygorenko, DM Volochnyuk… - European Journal of …, 2021 - Wiley Online Library
Current medicinal chemistry relies heavily on the quality of building blocks, ie reagents used
to introduce chemical diversity into the target molecules. The last decade witnessed an …
to introduce chemical diversity into the target molecules. The last decade witnessed an …
Thiazole derivatives in medicinal chemistry: Recent advancements in synthetic strategies, structure activity relationship and pharmacological outcomes
Thiazole derivatives remains honored heterocycles in the field of medicinal chemistry. This
scaffold has been proven as a universal motif that is present in numerous pharmacologically …
scaffold has been proven as a universal motif that is present in numerous pharmacologically …
Discovery of ligustrazine and chalcone derivatives as novel viral nucleoprotein nuclear export inhibitors against influenza viruses
P Li, H Ju, Y Zhang, JG Achi, D Kang… - Journal of Medical …, 2023 - Wiley Online Library
Influenza viruses pose a significant threat to human health worldwide due to seasonal
epidemics and occasional global pandemics. These viruses can cause severe upper …
epidemics and occasional global pandemics. These viruses can cause severe upper …
Anno 2021: Which antivirals for the coming decade?
E Groaz, E De Clercq, P Herdewijn - Annual Reports in Medicinal …, 2021 - Elsevier
Despite considerable progress in the development of antiviral drugs, among which anti-
immunodeficiency virus (HIV) and anti-hepatitis C virus (HCV) medications can be …
immunodeficiency virus (HIV) and anti-hepatitis C virus (HCV) medications can be …
Amphiphilic Polyfluorinated Amino Ethers from Cyclic Sulfamidates
N Marie, JA Ma, D Cahard - The Journal of Organic Chemistry, 2022 - ACS Publications
Regioselective ring opening of cyclic sulfamidates was achieved by means of nucleophilic
polyfluorinated alkoxides to access achiral and chiral β-and γ-ORF amines and α-amino …
polyfluorinated alkoxides to access achiral and chiral β-and γ-ORF amines and α-amino …
Anti-influenza drug discovery and development: targeting the virus and its host by all possible means
O Terrier, A Slama-Schwok - Antiviral Drug Discovery and Development, 2021 - Springer
Infections by influenza virus constitute a major and recurrent threat for human health.
Together with vaccines, antiviral drugs play a key role in the prevention and treatment of …
Together with vaccines, antiviral drugs play a key role in the prevention and treatment of …
1, 3-Thiazole Derivatives as a Promising Scaffold in Medicinal Chemistry: A Recent Overview
P Kushwaha, S Pandey - … -Inflammatory & Anti-Allergy Agents in …, 2023 - ingentaconnect.com
The thiazole ring is a unique heterocyclic motif among heterocyclic compounds. This five-
member ring with one nitrogen and one sulphur atom displays a wide array of …
member ring with one nitrogen and one sulphur atom displays a wide array of …
[HTML][HTML] The Oncogenic Fusion Protein EML4-NTRK3 Requires Three Salt Bridges for Stability and Biological Activity
Z Jiang, AN Meyer, W Yang, DJ Donoghue - Heliyon, 2024 - cell.com
Aim of study Chromosomal translocations involving neurotrophic receptor tyrosine kinases
(NTRKs) have been identified in 20% of soft tissue sarcomas. This work focuses on the …
(NTRKs) have been identified in 20% of soft tissue sarcomas. This work focuses on the …
[HTML][HTML] Designing a bis-azide photoaffinity probe in labeling influenza nucleoprotein trimer to give an insight into the binding mode
PH Chiu, W Huang, HT Hsu, WF Huang, YT Wu… - European Journal of …, 2022 - Elsevier
Targeting the highly conserved E330… R416 salt bridge involved in nucleoprotein (NP)
trimerization is considered a favorable approach to address the problem of drug resistance …
trimerization is considered a favorable approach to address the problem of drug resistance …
[HTML][HTML] A Quinolinone compound inhibiting the oligomerization of nucleoprotein of influenza A virus prevents the selection of escape mutants
JN Makau, K Watanabe, H Otaki, S Mizuta, T Ishikawa… - Viruses, 2020 - mdpi.com
The emergence of resistance to currently available anti-influenza drugs has heightened the
need for antivirals with novel mechanisms of action. The influenza A virus (IAV) …
need for antivirals with novel mechanisms of action. The influenza A virus (IAV) …