Current medicinal chemistry relies heavily on the quality of building blocks, ie reagents used
to introduce chemical diversity into the target molecules. The last decade witnessed an …

Thiazole derivatives remains honored heterocycles in the field of medicinal chemistry. This
scaffold has been proven as a universal motif that is present in numerous pharmacologically …

Influenza viruses pose a significant threat to human health worldwide due to seasonal
epidemics and occasional global pandemics. These viruses can cause severe upper …

Despite considerable progress in the development of antiviral drugs, among which anti-
immunodeficiency virus (HIV) and anti-hepatitis C virus (HCV) medications can be …

Regioselective ring opening of cyclic sulfamidates was achieved by means of nucleophilic
polyfluorinated alkoxides to access achiral and chiral β-and γ-ORF amines and α-amino …

Infections by influenza virus constitute a major and recurrent threat for human health.
Together with vaccines, antiviral drugs play a key role in the prevention and treatment of …

The thiazole ring is a unique heterocyclic motif among heterocyclic compounds. This five-
member ring with one nitrogen and one sulphur atom displays a wide array of …

Aim of study Chromosomal translocations involving neurotrophic receptor tyrosine kinases
(NTRKs) have been identified in 20% of soft tissue sarcomas. This work focuses on the …

Targeting the highly conserved E330… R416 salt bridge involved in nucleoprotein (NP)
trimerization is considered a favorable approach to address the problem of drug resistance …

The emergence of resistance to currently available anti-influenza drugs has heightened the
need for antivirals with novel mechanisms of action. The influenza A virus (IAV) …