The multifaceted role of reactive oxygen species in tumorigenesis
Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …
various normal cellular functions including cellular growth, differentiation, senescence …
Cancer stem cells: A brief review of the current status
Cancer stem cells (CSCs) comprise the subpopulation of tumor bulk and acquire resistant to
conventional therapies and are considered as the primary tumor initiator cells. Nowadays …
conventional therapies and are considered as the primary tumor initiator cells. Nowadays …
Interplay of EMT and CSC in Cancer and the Potential Therapeutic Strategies
S Tanabe, S Quader, H Cabral, R Ono - Frontiers in pharmacology, 2020 - frontiersin.org
The mechanism of epithelial-mesenchymal transition (EMT) consists of the cellular
phenotypic transition from epithelial to mesenchymal status. The cells exhibiting EMT exist in …
phenotypic transition from epithelial to mesenchymal status. The cells exhibiting EMT exist in …
Palmatine, a Bioactive Protoberberine Alkaloid Isolated from Berberis cretica, Inhibits the Growth of Human Estrogen Receptor-Positive Breast Cancer Cells and Acts …
A Grabarska, P Wróblewska-Łuczka, W Kukula-Koch… - Molecules, 2021 - mdpi.com
Palmatine (PLT) is a natural isoquinoline alkaloid that belongs to the class of
protoberberines and exhibits a wide spectrum of pharmacological and biological properties …
protoberberines and exhibits a wide spectrum of pharmacological and biological properties …
The long noncoding RNA CRAL reverses cisplatin resistance via the miR-505/CYLD/AKT axis in human gastric cancer cells
Z Wang, Q Wang, G Xu, N Meng, X Huang, Z Jiang… - RNA biology, 2020 - Taylor & Francis
Emerging evidence has suggested that long noncoding RNAs (lncRNAs) play an essential
role in the tumorigenesis of multiple types of cancer including gastric cancer (GC). However …
role in the tumorigenesis of multiple types of cancer including gastric cancer (GC). However …
Natural borneol sensitizes human glioma cells to cisplatin-induced apoptosis by triggering ROS-mediated oxidative damage and regulation of MAPKs and PI3K/AKT …
W Cao, X Zhai, J Ma, X Fu, B Zhao, P Zhang… - Pharmaceutical …, 2020 - Taylor & Francis
Context Cisplatin-based chemotherapy was widely used in treating human malignancies.
However, side effects and chemoresistance remains the major obstacle. Objective To verify …
However, side effects and chemoresistance remains the major obstacle. Objective To verify …
Chiral RuII‐PtII Complexes Inducing Telomere Dysfunction against Cisplatin‐Resistant Cancer Cells
K Xiong, C Ouyang, J Liu, J Karges, X Lin… - Angewandte …, 2022 - Wiley Online Library
The application of G‐quadruplex stabilizers presents a promising anticancer strategy.
However, the molecular crowding conditions within cells diminish the potency of current G …
However, the molecular crowding conditions within cells diminish the potency of current G …
The role of telomerase in breast Cancer's response to Therapy
E Judasz, N Lisiak, P Kopczyński, M Taube… - International journal of …, 2022 - mdpi.com
Currently, breast cancer appears to be the most widespread cancer in the world and the
most common cause of cancer deaths. This specific type of cancer affects women in both …
most common cause of cancer deaths. This specific type of cancer affects women in both …
Anti-cancer immunotherapies targeting telomerase
S Negrini, R De Palma, G Filaci - Cancers, 2020 - mdpi.com
Telomerase is a reverse transcriptase that maintains telomeres length, compensating for the
attrition of chromosomal ends that occurs during each replication cycle. Telomerase is …
attrition of chromosomal ends that occurs during each replication cycle. Telomerase is …
Targeting HMGB3/hTERT axis for radioresistance in cervical cancer
Z Li, Y Zhang, S Sui, Y Hua, A Zhao, X Tian… - Journal of Experimental …, 2020 - Springer
Background Radiotherapy is regarded as a milestone for the cure of cervical cancer.
However, clinical outcome heavily be hindered by radioresistance. So, exploring the …
However, clinical outcome heavily be hindered by radioresistance. So, exploring the …